From: Biology and therapy of fibromyalgia. New therapies in fibromyalgia
Study | Drug (mg/day) | Study design (no. of patients) | Duration (weeks) | Outcomes that significantly improved with treatment over placebo |
---|---|---|---|---|
SNRI | Â | Â | Â | Â |
   Arnold et al. [55] | Duloxetine (120) | Duloxetine v placebo, parallel (207) | 12 | Primary measure: FIQ total score (FIQ pain score improved in women only) |
 |  |  |  | Secondary measures: FIQ stiffness scores, BPI pain severity and interference from pain, tender points, CGI-S, PGI-I, QLDS, SDS, SF-36 physical subscore and bodily pain, general health perception, mental health, physical function, vitality scores |
   Gendreau et al. [65] | Milnacipran (up to 200) | Milnacipran v placebo, parallel (125) | 12 | Secondary measures: Pain (weekly e-diary pain score, paper daily and weekly scores, present pain score), patient global impression of change, FIQ physical function, days felt good, pain, fatigue, and morning stiffness scores |
   Arnold et al. [63] | Duloxetine (60 and 120) | Duloxetine v placebo, parallel (354) | 12 | Primary measure: BPI average pain severity |
 |  |  |  | Secondary measures: BPI interference from pain, FIQ total score, tender points (120 mg only), CGI-S, PGI-I, QLDS, SDS, SF-36 mental subscore and scores for social function (60 mg only), physical function (120 mg only), bodily pain, mental health, role limit emotional and physical, and vitality |
Alpha 2 delta | Â | Â | Â | Â |
   Crofford et al. [67] | Pregabalin (150, 300, and 450) | Pregabalin v placebo, parallel (529) | 8 | Primary measure: mean daily pain score (daily diaries) (450 mg only) |
 |  |  |  | Secondary measures: sleep quality diary (300 mg, 450 mg), MAF global fatigue (300 mg, 450 mg), patient and clinician global impression of change (300 mg, 450 mg), SF-36 general health (150 mg, 300 mg, 450 mg), vitality (450 mg), bodily pain (450 mg), social functioning (450 mg) |