Corticosteroids
|
Prednisone
|
C
|
Oral clefts increased risk (two- to three-fold). Intrauterine growth restriction (dose related)
|
Based on available data, teratogenic risk for corticosteroids is minimal
|
|
Cortisone
|
D
| | |
|
All others
|
C
| | |
NSAIDs
|
Celecoxib
|
C
|
Ibuprofen associated with increased risk (two- to three-fold) for gastroschisis. NSAIDs associated with increased risk for spontaneous abortion; possible increased risk for cardiac defects; premature closure of the ductus arteriosus with third trimester use
|
Significant risk for premature closure of the ductus arteriosus and other complications when exposure occurs in late pregnancy; minimal or undetermined risk for structural defects following first trimester exposure
|
|
Diclofenac
|
C
| | |
|
Ketorolac
|
C
| | |
|
Prixicam
|
C
| | |
|
All others
|
B
| | |
|
All NSAIDs in third trimester
|
D
| | |