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Table 1 Clinical characteristics of patients

From: NOS2polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity

Characteristic SSc patients   Healthy controls
  With PAH Without PAH  
Number at entry (n (male:female) 20 (1:19) 58 (5:53) 95 (8:87)
Age (years; mean (range) 48.6 (17–80) 47.7 (19–77) 40.9 (22–78)
Diffuse SSc:limited SSc (n) 6:14 33:25  
Disease duration (months; mean (range) 42.0 (6–130) 41.9 (5–120)  
Pulmonary fibrosis (n (%) 6 (30) 31 (53)  
Frequency of ANA (n (%)
   Anti-U1-snRNP antibody 11 (55) 17 (29) 0
   Anti-topoisomerase I antibody 1 (5) 13 (22) 0
   Anti-centromere antibody 5 (25) 12 (21) 0
  1. ANA, antinuclear antibody; PAH, pulmonary arterial hypertension; SSc, systemic sclerosis.