Table 1 Examples of autoantigens involved in RNA metabolic processes
From: The RNA interference pathway: a new target for autoimmunity
Autoantigen | Ribonucleoprotein complex | Target protein(s) | Subcellular localization | Process |
|---|---|---|---|---|
Sm | U snRNP | Sm proteins | Nucleoplasm | Pre-mRNA splicing |
Ro | Y RNP | Ro60 | Cytoplasm | RNA quality control |
La | La RNP | La protein | Nucleoplasm | Maturation RNA Pol III transcripts |
Th/To | RNase MRP, RNase P | Rpp38, Rpp25, Rpp20 | Nucleoli | Pre-rRNA processing |
Su | RISC | Ago, Dicer | Cytoplasm | RNAi |