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Table 4 Transcripts as predictors of infliximab responsiveness

From: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis

IMAGE clonea Encoded protein Symbolb Gene localisation SAMc t testd
295669 Clone 10PTELO13 - - -3.77 0.001
77684 CytP450, family 3, subfamily A, polypeptide 4 CYP3A4 7q21.1 -2.90 <10-4
417137 A kinase (PRKA) anchor protein 9 AKAP9 7q21-q22 -2.83 0.002
415079 Hypothetical protein DKFZp566M1046 - - -2.78 0.001
1848509 RP1 containing part of thyroid hormone receptor-associated protein 3 THRAP3 1p34.3 -2.56 NS
234261 RP11-750K11 - - -2.53 NS
198699 C-X-C chemokine ligand 5 (ENA78) CXCL5 4q12-q13 -2.50 NS
730048 Ribosomal protein SA (37LRP) LAMR1 3p21.3 -2.43 0.007
56923 F-box protein 5 FBXO5 6q25-q26 -2.42 0.006
1524020 RAS guanyl releasing protein 3 (calcium and DAG-regulated) RASGRP3 2p25.1-p24.1 -2.41 0.004
756784 WD repeat domain 39 WDR39 2q11.2 -2.40 NS
244313 Bac clone RP11-576F1 - - -2.39 0.002
124452 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 3p22-p21 -2.33 0.003
724887 Major HLA, class II, DP beta 1 HLA-DPB1 6p21.3 -2.32 <10-4
416493 Ribosomal protein L35 RPL35 9q34.1 -2.25 NS
191599 Hypothetical protein FLJ13614 - - -2.23 0.006
726045 Ribosomal protein S16 RPS16 19q13.1 -2.24 NS
772993 Similar to 40S ribosomal protein S28 RPS28 19p13.2 -2.23 NS
110169 Proteasome subunit β type 9 (LMP2) PSMB9 6p21.3 -2.17 0.006
346678 Musculoskeletal, embryonic nucleic protein 1 MUSTN1 3p21.1 -2.16 NS
741027 Vinexin β (SH3-containing adaptor molecule-1) SCAM-1 8p21.3 -2.15 NS
428222 EGF receptor pathway substrate 15 EPS15 1p32 -2.12 0.003
740374 Transducin (beta)-like 2 TBL2 7q11.23 -2.12 Ns
774502 Protein tyrosine phosphatase, non-receptor type 12 PTPN12 7q11.23 -2.09 NS
320298 Membrane-type 1 matrix metalloprotein cytoplasmic tail binding protein 1 MTCBP-1 2p25.2 -2.04 0.005
148134 RP1-29K1 containing KiAA0426 - - NS 0.002
127203 CytP450, family 4, subfamily F, polypeptide 12 CYP4F12 19p13.1 NS 0.005
428560 QIL1 protein QIL1 19p13.3 NS 0.009
810626 Cytochrome c oxidase subunit VIIa polypeptide 2 like COX7A2L 2p21 NS 0.007
123983 Clone PR13 - - +1.80 NS
486624 ELMO domain containing 2 ELMOD2 4q31.21 +1.85 NS
114519 FLJ 14775 - - +1.90 0.007
357960 Mitochondrial ribosomal protein L22 MRPL22 5q33.1-q33.3 +1.99 0.009
82303 Hypothetical protein BC009264 - - +2.12 NS
247517 Mucin and cadherin-like MUCDHL 11p15.5 +2.40 NS
194455 Membrane cofactor protein (CD46) MCP 1q32 +2.30 0.005
247176 RP116103J18 - - +2.41 <10-4
195723 Kininogen 1 KNG1 -3q27 +2.46 0.009
239932 ELAC homolog 2 - - +2.46 NS
244896 Aminoadipate aminotransferase AADAT 4q33 +2.52 0.002
193472 RP11-722P15 - - +2.68 0.002
  1. aIMAGE clone number as a unique identifier. bBold indicates a transcript that was further tested by qRT-PCR. cSignificance analysis of microarrays (SAM) value as an indicator of significant transcript variation in responders versus non-responders. A positive or negative value indicates an over- or underexpression at baseline in responders versus non-responders, respectively. dP value of a t test as an indicator of significant transcript variation in responders versus non-responders. NS, non- significant.