Table 4 Transcripts as predictors of infliximab responsiveness
From: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis
IMAGE clonea | Encoded protein | Symbolb | Gene localisation | SAMc | t testd |
|---|---|---|---|---|---|
295669 | Clone 10PTELO13 | - | - | -3.77 | 0.001 |
77684 | CytP450, family 3, subfamily A, polypeptide 4 | CYP3A4 | 7q21.1 | -2.90 | <10-4 |
417137 | A kinase (PRKA) anchor protein 9 | AKAP9 | 7q21-q22 | -2.83 | 0.002 |
415079 | Hypothetical protein DKFZp566M1046 | - | - | -2.78 | 0.001 |
1848509 | RP1 containing part of thyroid hormone receptor-associated protein 3 | THRAP3 | 1p34.3 | -2.56 | NS |
234261 | RP11-750K11 | - | - | -2.53 | NS |
198699 | C-X-C chemokine ligand 5 (ENA78) | CXCL5 | 4q12-q13 | -2.50 | NS |
730048 | Ribosomal protein SA (37LRP) | LAMR1 | 3p21.3 | -2.43 | 0.007 |
56923 | F-box protein 5 | FBXO5 | 6q25-q26 | -2.42 | 0.006 |
1524020 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | RASGRP3 | 2p25.1-p24.1 | -2.41 | 0.004 |
756784 | WD repeat domain 39 | WDR39 | 2q11.2 | -2.40 | NS |
244313 | Bac clone RP11-576F1 | - | - | -2.39 | 0.002 |
124452 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | PFKFB4 | 3p22-p21 | -2.33 | 0.003 |
724887 | Major HLA, class II, DP beta 1 | HLA-DPB1 | 6p21.3 | -2.32 | <10-4 |
416493 | Ribosomal protein L35 | RPL35 | 9q34.1 | -2.25 | NS |
191599 | Hypothetical protein FLJ13614 | - | - | -2.23 | 0.006 |
726045 | Ribosomal protein S16 | RPS16 | 19q13.1 | -2.24 | NS |
772993 | Similar to 40S ribosomal protein S28 | RPS28 | 19p13.2 | -2.23 | NS |
110169 | Proteasome subunit β type 9 (LMP2) | PSMB9 | 6p21.3 | -2.17 | 0.006 |
346678 | Musculoskeletal, embryonic nucleic protein 1 | MUSTN1 | 3p21.1 | -2.16 | NS |
741027 | Vinexin β (SH3-containing adaptor molecule-1) | SCAM-1 | 8p21.3 | -2.15 | NS |
428222 | EGF receptor pathway substrate 15 | EPS15 | 1p32 | -2.12 | 0.003 |
740374 | Transducin (beta)-like 2 | TBL2 | 7q11.23 | -2.12 | Ns |
774502 | Protein tyrosine phosphatase, non-receptor type 12 | PTPN12 | 7q11.23 | -2.09 | NS |
320298 | Membrane-type 1 matrix metalloprotein cytoplasmic tail binding protein 1 | MTCBP-1 | 2p25.2 | -2.04 | 0.005 |
148134 | RP1-29K1 containing KiAA0426 | - | - | NS | 0.002 |
127203 | CytP450, family 4, subfamily F, polypeptide 12 | CYP4F12 | 19p13.1 | NS | 0.005 |
428560 | QIL1 protein | QIL1 | 19p13.3 | NS | 0.009 |
810626 | Cytochrome c oxidase subunit VIIa polypeptide 2 like | COX7A2L | 2p21 | NS | 0.007 |
123983 | Clone PR13 | - | - | +1.80 | NS |
486624 | ELMO domain containing 2 | ELMOD2 | 4q31.21 | +1.85 | NS |
114519 | FLJ 14775 | - | - | +1.90 | 0.007 |
357960 | Mitochondrial ribosomal protein L22 | MRPL22 | 5q33.1-q33.3 | +1.99 | 0.009 |
82303 | Hypothetical protein BC009264 | - | - | +2.12 | NS |
247517 | Mucin and cadherin-like | MUCDHL | 11p15.5 | +2.40 | NS |
194455 | Membrane cofactor protein (CD46) | MCP | 1q32 | +2.30 | 0.005 |
247176 | RP116103J18 | - | - | +2.41 | <10-4 |
195723 | Kininogen 1 | KNG1 | -3q27 | +2.46 | 0.009 |
239932 | ELAC homolog 2 | - | - | +2.46 | NS |
244896 | Aminoadipate aminotransferase | AADAT | 4q33 | +2.52 | 0.002 |
193472 | RP11-722P15 | - | - | +2.68 | 0.002 |