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Table 5 Performance of the number of transcripts for prediction of responsiveness

From: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis

 

Number of selected transcriptsa

 

20

8

Number of NR patients classified as NRb

7

10

Number of NR patients classified as Rb

3

0

Number of R patients classified as Rb

9

8

Number of R patients classified as NRb

1

2

Fisher's exact testc

p < 0.02

p < 0.0007

Sensitivity

90%

80%

Specificity

70%

100%

Positive predictive value

75%

100%

Negative predictive value

87.5%

83%

  1. aAs listed in Figure 2a, b. bBy leave-one-out cross-validation with 20 patients, including 10 non-responders (NR) and 10 responders (R) (referred to as validation subset 2 in the text). cP < 0.05 indicates a significant link between transcript-based classification (R versus NR) and actual responsiveness.