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Table 5 Performance of the number of transcripts for prediction of responsiveness

From: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis

  Number of selected transcriptsa
  20 8
Number of NR patients classified as NRb 7 10
Number of NR patients classified as Rb 3 0
Number of R patients classified as Rb 9 8
Number of R patients classified as NRb 1 2
Fisher's exact testc p < 0.02 p < 0.0007
Sensitivity 90% 80%
Specificity 70% 100%
Positive predictive value 75% 100%
Negative predictive value 87.5% 83%
  1. aAs listed in Figure 2a, b. bBy leave-one-out cross-validation with 20 patients, including 10 non-responders (NR) and 10 responders (R) (referred to as validation subset 2 in the text). cP < 0.05 indicates a significant link between transcript-based classification (R versus NR) and actual responsiveness.