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Table 3 Sensitivity, PPV, and NPV of the DAS28 to predict infliximab discontinuation due to lack of efficacy

From: Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity

  DAS28 at week 14 DAS28 at week 22
Specificity level Cutoff Sensitivity PPV NPV Cutoff Sensitivity PPV NPV
0.90 5.47 0.36 0.34 0.90 5.55 0.41 0.41 0.90
0.95 5.97 0.35 0.51 0.90 6.10 0.37 0.56 0.91
0.98 6.40 0.32 0.90 0.90 6.85 0.16 0.62 0.89
  1. Sensitivities, PPVs, and NPVs are presented at different specificity levels of the DAS28 at week 14 or 22. DAS28, disease activity score based on the 28-joint count; NPV, negative predictive value; PPV, positive predictive value.