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Table 2 List of all the Gene Ontology significant terms with more than two annotated genes on the array (N > 2)

From: A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients

GO category number GO term P value n/N Genes
6412 Protein biosynthesis <0.001 15/205 EIF4G1(↑), ITGB4BP(↑), LAMR1(↑), RPL7(↑), RPL9(↑), RPL10(↑), RPL12(↑), RPL23A(↑), RPS5(↑), RPS10(↑), RPS20(↑), RPL14(↑), NOLA2(↑), RPL10A(↑), RPL38(↑)
50930 Induction of positive chemotaxis 0.002 2/4 AZU1(↓), IL8(↑)
6878 Copper ion homeostasis 0.002 2/4 ATOX1(↑), MT2A(↑)
6337 Nucleosome disassembly 0.002 2/4 HMGA1(↑), SUPT16H(↑)
6508 Proteolysis and peptidolysis 0.002 13/290 ANPEP(↑), AZU1(↓), CAPN2(↑), NEDD8(↑), PLAT(↑), PLAU, PRSS1(↓), ADAM15(↑), NPEPPS(↑), KLK11(↓), SUPT16H(↑), CASP14(↓), KLK12(↓)
7266 Rho protein signal transduction 0.004 3/18 RHOA(↑), ARHGDIB(↑), CFL1(↑)
1516 Prostaglandin biosynthesis 0.008 2/8 MIF(↑), PTGDS(↓)
30036 Actin cytoskeleton organization and biogenesis 0.010 4/47 RHOA(↑), ARHGDIB(↑), CFL1(↑), PFN1(↑)
42157 Lipoprotein metabolism 0.011 2/9 APOA1(↓), HMGA1(↑)
6928 Cell motility 0.012 6/104 ACTN4(↑), CTGF(↑), IL8(↑), SPOCK(↑), ACTR3(↑), ARPC2(↑)
43065 Positive regulation of apoptosis 0.013 2/10 BCL2L11(↓), MTCH1(↑)
6445 Regulation of translation 0.014 3/28 MKNK2(↑), LAMR1(↑), PPP2CA(↑)
43066 Negative regulation of apoptosis 0.016 2/11 MIF(↑), ANGPTL4(↑)
30155 Regulation of cell adhesion 0.019 2/12 IL8(↑), PPP2CA(↑)
6979 Response to oxidative stress 0.024 3/34 ATOX1(↑), DUSP1(↑), GPX2(↓)
7596 Blood coagulation 0.026 4/61 GP9(↓), PLAT(↑), PLAU(↑), THBD(↑)
6869 Lipid transport 0.026 3/35 APOA1(↓), HMGA1(↑), LBP(↓)
9611 Response to wounding 0.030 2/15 CTGF(↑), MDK(↑)
6355 Regulation of transcription, DNA-dependent 0.037 11/1,042 BTF3L3(↑), RUNX2(↓), ENO1(↓), GATA6(↓), HMGA1(↓), FOXA2(↓), NFKB2(↓), SSRP1(↑), UBE2V1(↑), NFAT5(↓), SIX4(↓)
45941 Positive regulation of transcription 0.047 2/19 GATA6(↓), HMGA1(↑)
7243 Protein kinase cascade 0.047 3/44 MKNK2(↑), STK17A(↓), MAP4K1(↓)
7605 Perception of sound 0.048 4/74 GJA1(↑), PMP22(↑), WDR1(↑), TIMM8B(↑)
  1. P values were determined by Fisher's exact test. Genes is a list of differentially expressed genes annotated to the GO terms; upward and downward arrows indicate up- and down-regulation, respectively. GO, gene ontology; n, number of differentially expressed genes annotated to the GO term; N, number of genes represented on the array annotated to the GO term;