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Table 2 List of all the Gene Ontology significant terms with more than two annotated genes on the array (N > 2)

From: A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients

GO category number

GO term

P value

n/N

Genes

6412

Protein biosynthesis

<0.001

15/205

EIF4G1(↑), ITGB4BP(↑), LAMR1(↑), RPL7(↑), RPL9(↑), RPL10(↑), RPL12(↑), RPL23A(↑), RPS5(↑), RPS10(↑), RPS20(↑), RPL14(↑), NOLA2(↑), RPL10A(↑), RPL38(↑)

50930

Induction of positive chemotaxis

0.002

2/4

AZU1(↓), IL8(↑)

6878

Copper ion homeostasis

0.002

2/4

ATOX1(↑), MT2A(↑)

6337

Nucleosome disassembly

0.002

2/4

HMGA1(↑), SUPT16H(↑)

6508

Proteolysis and peptidolysis

0.002

13/290

ANPEP(↑), AZU1(↓), CAPN2(↑), NEDD8(↑), PLAT(↑), PLAU, PRSS1(↓), ADAM15(↑), NPEPPS(↑), KLK11(↓), SUPT16H(↑), CASP14(↓), KLK12(↓)

7266

Rho protein signal transduction

0.004

3/18

RHOA(↑), ARHGDIB(↑), CFL1(↑)

1516

Prostaglandin biosynthesis

0.008

2/8

MIF(↑), PTGDS(↓)

30036

Actin cytoskeleton organization and biogenesis

0.010

4/47

RHOA(↑), ARHGDIB(↑), CFL1(↑), PFN1(↑)

42157

Lipoprotein metabolism

0.011

2/9

APOA1(↓), HMGA1(↑)

6928

Cell motility

0.012

6/104

ACTN4(↑), CTGF(↑), IL8(↑), SPOCK(↑), ACTR3(↑), ARPC2(↑)

43065

Positive regulation of apoptosis

0.013

2/10

BCL2L11(↓), MTCH1(↑)

6445

Regulation of translation

0.014

3/28

MKNK2(↑), LAMR1(↑), PPP2CA(↑)

43066

Negative regulation of apoptosis

0.016

2/11

MIF(↑), ANGPTL4(↑)

30155

Regulation of cell adhesion

0.019

2/12

IL8(↑), PPP2CA(↑)

6979

Response to oxidative stress

0.024

3/34

ATOX1(↑), DUSP1(↑), GPX2(↓)

7596

Blood coagulation

0.026

4/61

GP9(↓), PLAT(↑), PLAU(↑), THBD(↑)

6869

Lipid transport

0.026

3/35

APOA1(↓), HMGA1(↑), LBP(↓)

9611

Response to wounding

0.030

2/15

CTGF(↑), MDK(↑)

6355

Regulation of transcription, DNA-dependent

0.037

11/1,042

BTF3L3(↑), RUNX2(↓), ENO1(↓), GATA6(↓), HMGA1(↓), FOXA2(↓), NFKB2(↓), SSRP1(↑), UBE2V1(↑), NFAT5(↓), SIX4(↓)

45941

Positive regulation of transcription

0.047

2/19

GATA6(↓), HMGA1(↑)

7243

Protein kinase cascade

0.047

3/44

MKNK2(↑), STK17A(↓), MAP4K1(↓)

7605

Perception of sound

0.048

4/74

GJA1(↑), PMP22(↑), WDR1(↑), TIMM8B(↑)

  1. P values were determined by Fisher's exact test. Genes is a list of differentially expressed genes annotated to the GO terms; upward and downward arrows indicate up- and down-regulation, respectively. GO, gene ontology; n, number of differentially expressed genes annotated to the GO term; N, number of genes represented on the array annotated to the GO term;