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Table 3 Class distribution of differentially expressed genes with a log odds ratio >1

From: A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients

Gene symbol

Gene title

M

Angiogenesis

  

MT1A

↑ Metallothionein 1A

3.25

PLAT

↑ Plasminogen activator, tissue

2.23

ANGPTL4

↑ Angiopoietin-like 4

1.97

CTGF

↑ Connective tissue growth factor

1.80

ENO1

↑ Enolase 1

1.67

PTX3

↑ Pentaxin-related gene, rapidly induced by IL-1 beta

1.66

VCL

↑ Vinculin

1.65

LAMR1

↑ Laminin receptor 1

1.63

PFN1

↑ Profilin 1

1.54

MT2A

↑ Metallothionein 2A

1.50

SPOCK

↑ Sparc/osteonectin (testican)

1.46

MT1E

↑ Metallothionein 1E

1.43

CCND1

↑ Cyclin D1

1.40

CFL1

↑ Cofilin 1

1.31

CAPN2

↑ Calpain 2, large subunit

1.28

MIF

↑ Macrophage migration inhibitory factor

1.24

WDR1

↑ WD repeat domain 1

1.21

IL8

↑ IL8

1.18

CLSTN1

↑ Calsyntenin 1

1.07

ADAM15

↑ A disintegrin and metalloproteinase domain 15

1.06

EFEMP1

↑ EGF-containing fibulin-like extracellular matrix protein 1

1.03

KLK9

↓ Kallikrein 9

-1.23

PLXNB1

↓ Plexin B1

-1.19

KLK12

↓ Kallikrein 12

-1.08

KLK11

↓ Kallikrein 11

-1.08

DSG2

↓ Desmoglein 2

-1.04

Apoptosis

  

TNFRSF6B

↑ Tumor necrosis factor receptor superfamily, member 6b, decoy

2.20

PRG1

↑ Proteoglycan 1, secretory granule

1.32

CFL1

↑ Cofilin 1

1.31

CAPN2

↑ Calpain 2, (m/II) large subunit

1.28

SGK

↑ Serum/glucocorticoid regulated kinase

1.27

MIF

↑ Macrophage migration inhibitory factor

1.24

PEA15

↑ Phosphoprotein enriched in astrocytes 15

1.23

MTCH1

↑ Mitochondrial carrier homolog 1

1.08

Haemostasis, inflammation and immunity

  

PLAT

↑ Plasminogen activator, tissue

2.23

ENO1

↑ Enolase 1

1.67

PTX3

↑ Pentaxin-related gene

1.66

IFITM2

↑ Interferon induced transmembrane protein 2

1.27

B2M

↑ Beta-2-microglobulin

1.26

ILF2

↑ Interleukin enhancer binding factor 2

1.15

LBP

↓ Lipopolysaccharide binding protein

-1.77

PTGDS

↓ Prostaglandin D2 synthase 21 kDa

-1.14

AZU1

↓ Azurocidin 1

-1.02

Stress/ubiquitination

  

ATOX1

↑ ATX1 antioxidant protein 1 homolog

1.51

UCHL1

↑ Ubiquitin carboxy-terminal esterase L1

1.33

ANAPC11

↑ Anaphase promoting complex subunit 11 homolog

1.28

FTL

↑ Ferritin, light polypeptide

1.25

PMP22

↑ Peripheral myelin protein 22

1.19

SLC38A2

↑ Solute carrier family 38, member 2

1.14

PSMC1

↑ Proteasome (prosome, macropain) 26S subunit, ATPase, 1

1.12

FKBP4

↑ FK506 binding protein 4

1.12

PSMD13

↑ Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

1.03

PRDX1

↑ Peroxiredoxin 1.

1.02

ANAPC10

↓ Anaphase promoting complex subunit 10

-1.22

Transduction

  

GJA1

↑ Gap junction protein, alpha 1, 43 kDa (connexin 43)

1.39

HPCAL1

↑ Hippocalcin-like 1

1.36

CFL1

↑ Cofilin 1

1.31

RAC2

↑ Ras-related C3 botulinum toxin substrate 2

1.30

SGK

↑ Serum/glucocorticoid regulated kinase

1.27

IL6ST

↑ Interleukin 6 signal transducer (gp130, oncostatin M receptor)

1.15

ARHGDIB

↑ Rho GDP dissociation inhibitor beta

1.10

GNG10

↑ Guanine nucleotide binding protein, gamma 10

1.05

PRDX4

↑ Peroxiredoxin 4

1.05

RHOA

↑ Ras homolog gene family, member A

1.02

PLXNB1

↓ Plexin B1

-1.19

MAP4K1

↓ Mitogen-activated protein kinase/kinase/kinase/kinase 1

-1.05

DNA/RNA organization

  

SBDS/CGI97

↑ Shwachman-Bodian-Diamond syndrome

2.14

ENO1

↑ Enolase 1

1.67

H3F3B

↑ H3 histone, family 3B

1.37

TRUB2

↓ TruB pseudouridine synthase homolog 2

-1.23

AVPI1

↓ Arginine vasopressin-induced 1

-1.12

C1orf34

↓ Chromosome 1 open reading frame 34

-1.05

Transcription

  

BTF3L3

↑ Basic transcription factor 3, like 3

1.21

ILF2

↑ Interleukin enhancer binding factor 2

1.15

GATA6

↓ GATA binding protein 6

-2.19

SOX9

↓ SRY (sex determining region Y)-box 9

-1.99

RUNX2

↓ Runt-related transcription factor 2

-1.16

NFAT5

↓ Nuclear factor of activated T-cells 5

-1.14

SOX5P

↓ SRY (sex determining region Y)-box 5

-1.12

FOXA2

↓ Forkhead box A2

-1.10

  1. All genes with a log odds ratio >0 were considered significantly down-regulated (M < 0) or up-regulated (M > 0). The table reports only genes with M > 1 and M < 1. Upward and downward arrows indicate up- and down-regulation, respectively.