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Table 3 Class distribution of differentially expressed genes with a log odds ratio >1

From: A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients

Gene symbol Gene title M
Angiogenesis   
MT1A ↑ Metallothionein 1A 3.25
PLAT ↑ Plasminogen activator, tissue 2.23
ANGPTL4 ↑ Angiopoietin-like 4 1.97
CTGF ↑ Connective tissue growth factor 1.80
ENO1 ↑ Enolase 1 1.67
PTX3 ↑ Pentaxin-related gene, rapidly induced by IL-1 beta 1.66
VCL ↑ Vinculin 1.65
LAMR1 ↑ Laminin receptor 1 1.63
PFN1 ↑ Profilin 1 1.54
MT2A ↑ Metallothionein 2A 1.50
SPOCK ↑ Sparc/osteonectin (testican) 1.46
MT1E ↑ Metallothionein 1E 1.43
CCND1 ↑ Cyclin D1 1.40
CFL1 ↑ Cofilin 1 1.31
CAPN2 ↑ Calpain 2, large subunit 1.28
MIF ↑ Macrophage migration inhibitory factor 1.24
WDR1 ↑ WD repeat domain 1 1.21
IL8 ↑ IL8 1.18
CLSTN1 ↑ Calsyntenin 1 1.07
ADAM15 ↑ A disintegrin and metalloproteinase domain 15 1.06
EFEMP1 ↑ EGF-containing fibulin-like extracellular matrix protein 1 1.03
KLK9 ↓ Kallikrein 9 -1.23
PLXNB1 ↓ Plexin B1 -1.19
KLK12 ↓ Kallikrein 12 -1.08
KLK11 ↓ Kallikrein 11 -1.08
DSG2 ↓ Desmoglein 2 -1.04
Apoptosis   
TNFRSF6B ↑ Tumor necrosis factor receptor superfamily, member 6b, decoy 2.20
PRG1 ↑ Proteoglycan 1, secretory granule 1.32
CFL1 ↑ Cofilin 1 1.31
CAPN2 ↑ Calpain 2, (m/II) large subunit 1.28
SGK ↑ Serum/glucocorticoid regulated kinase 1.27
MIF ↑ Macrophage migration inhibitory factor 1.24
PEA15 ↑ Phosphoprotein enriched in astrocytes 15 1.23
MTCH1 ↑ Mitochondrial carrier homolog 1 1.08
Haemostasis, inflammation and immunity   
PLAT ↑ Plasminogen activator, tissue 2.23
ENO1 ↑ Enolase 1 1.67
PTX3 ↑ Pentaxin-related gene 1.66
IFITM2 ↑ Interferon induced transmembrane protein 2 1.27
B2M ↑ Beta-2-microglobulin 1.26
ILF2 ↑ Interleukin enhancer binding factor 2 1.15
LBP ↓ Lipopolysaccharide binding protein -1.77
PTGDS ↓ Prostaglandin D2 synthase 21 kDa -1.14
AZU1 ↓ Azurocidin 1 -1.02
Stress/ubiquitination   
ATOX1 ↑ ATX1 antioxidant protein 1 homolog 1.51
UCHL1 ↑ Ubiquitin carboxy-terminal esterase L1 1.33
ANAPC11 ↑ Anaphase promoting complex subunit 11 homolog 1.28
FTL ↑ Ferritin, light polypeptide 1.25
PMP22 ↑ Peripheral myelin protein 22 1.19
SLC38A2 ↑ Solute carrier family 38, member 2 1.14
PSMC1 ↑ Proteasome (prosome, macropain) 26S subunit, ATPase, 1 1.12
FKBP4 ↑ FK506 binding protein 4 1.12
PSMD13 ↑ Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 1.03
PRDX1 ↑ Peroxiredoxin 1. 1.02
ANAPC10 ↓ Anaphase promoting complex subunit 10 -1.22
Transduction   
GJA1 ↑ Gap junction protein, alpha 1, 43 kDa (connexin 43) 1.39
HPCAL1 ↑ Hippocalcin-like 1 1.36
CFL1 ↑ Cofilin 1 1.31
RAC2 ↑ Ras-related C3 botulinum toxin substrate 2 1.30
SGK ↑ Serum/glucocorticoid regulated kinase 1.27
IL6ST ↑ Interleukin 6 signal transducer (gp130, oncostatin M receptor) 1.15
ARHGDIB ↑ Rho GDP dissociation inhibitor beta 1.10
GNG10 ↑ Guanine nucleotide binding protein, gamma 10 1.05
PRDX4 ↑ Peroxiredoxin 4 1.05
RHOA ↑ Ras homolog gene family, member A 1.02
PLXNB1 ↓ Plexin B1 -1.19
MAP4K1 ↓ Mitogen-activated protein kinase/kinase/kinase/kinase 1 -1.05
DNA/RNA organization   
SBDS/CGI97 ↑ Shwachman-Bodian-Diamond syndrome 2.14
ENO1 ↑ Enolase 1 1.67
H3F3B ↑ H3 histone, family 3B 1.37
TRUB2 ↓ TruB pseudouridine synthase homolog 2 -1.23
AVPI1 ↓ Arginine vasopressin-induced 1 -1.12
C1orf34 ↓ Chromosome 1 open reading frame 34 -1.05
Transcription   
BTF3L3 ↑ Basic transcription factor 3, like 3 1.21
ILF2 ↑ Interleukin enhancer binding factor 2 1.15
GATA6 ↓ GATA binding protein 6 -2.19
SOX9 ↓ SRY (sex determining region Y)-box 9 -1.99
RUNX2 ↓ Runt-related transcription factor 2 -1.16
NFAT5 ↓ Nuclear factor of activated T-cells 5 -1.14
SOX5P ↓ SRY (sex determining region Y)-box 5 -1.12
FOXA2 ↓ Forkhead box A2 -1.10
  1. All genes with a log odds ratio >0 were considered significantly down-regulated (M < 0) or up-regulated (M > 0). The table reports only genes with M > 1 and M < 1. Upward and downward arrows indicate up- and down-regulation, respectively.