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Table 2 Effects of leptin or leptin receptor deficiency and leptin administration in disease models mediated by adaptive immune responses in mice

From: The role of leptin in innate and adaptive immune responses

Models WT mice ob/ob mice db/db mice Leptin injection References
Non-obese diabetic mice ↑ Serum leptin before onset of diabetes    ↑ Destruction of insulin-producing β-cells [75]
     ↑ IFN-γ production by T lymphocytes  
AIA   ↓ Arthritis severity ↓ Arthritis severity   [35]
   ↓ Anti-mBSA Abs ↓ Anti-mBSA Abs   
  Ex vivo T-cell proliferation Ex vivo T-cell proliferation   
   ↓ IFN-γ and ↓ IFN-γ and   
   ↑ IL-10 production ↑ IL-10 production   
EAE ↑ Serum leptin before onset of EAE Serum leptin correlated with EAE susceptibility ↓ Susceptibility   ↑ Severity in SJL females SJL males: become susceptible Restored susceptibility in ob/ob mice associated to Th2 to Th1 switch [42]
  Administration of anti-leptin Abs or soluble leptin receptors:     
  ↓ Disease severity     
T-cell mediated hepatitis   Protected from liver damage   ob/ob mice: restored susceptibility [70, 110]
   ↓ TNF-α and IL-18    
Colitis   ↓ Severity    [71]
   ↓ Local release of proinflammatory cytokines    
Immune-mediated glomerulonephritis   Protected    [74]
  1. Up and down arrows indicate increase and decrease, respectively. Abs, antibodies; AIA, antigen-induced arthritis; db/db, leptin receptor deficient mice; EAE, autoimmune encephalomyelitis; ob/ob, leptin deficient mice; Th, T helper; TNF, tumor necrosis factor; WT, wild-type.