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Figure 2 | Arthritis Research & Therapy

Figure 2

From: The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus

Figure 2

Phenotype, proliferation and cytokine production of heterogeneous nuclear ribonucleoprotein (hnRNP)-A2 specific T cell clones (TCCs) of systemic lupus erythematosus (SLE) patients and controls. TCCs were generated by limiting dilution and their specificity was assessed by measuring proliferation in response to hnRNP-A2. Cytokine production of TCCs was measured in the supernatants after 24 hours of stimulation with autologous antigen presenting cells and hnRNP-A2. (a) Proliferation of CD4+ and CD8+ TCCs of SLE patients. (b) Proliferation and IFNγ production of TCCs of SLE patients. (c) Proliferation of CD4+ and CD8+ TCCs of healthy controls (HCs). (d) Proliferation and IFNγ production of TCCs of healthy controls. There was no correlation between proliferative capacity and cytokine secretion.

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Arthritis Research & Therapy

ISSN: 1478-6362

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