From: Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis
RA | Non-RA | |||||
---|---|---|---|---|---|---|
Persistent | Resolving | |||||
Neutrophil | Lymphocyte | Neutrophil | Lymphocyte | Neutrophil | Lymphocyte | |
Number of patients from whom analyzable follow-up samples were available | 10 | 7 | 11 | 11 | 11 | 13 |
Number of analyzable follow-up samples | 16 | 12 | 25 | 26 | 17 | 21 |
Number of weeks after symptom onset when follow-up samples were collected (median [IQR]) | 19 (15–38) | 18 (13–39) | 26 (14–46) | 28 (14–46) | 13 (9–28) | 14 (9–22) |
Number of patients in whom more apoptosis was seen in a follow-up sample than in the initial sample | 2 | 2 | 6 | 4 | 4 | 7 |
Treatment received prior to follow-up joint aspiration where more apoptosis was seen at follow-up | ||||||
Nil | 0 | 1 | 1 | 0 | 0 | 1 |
Parenteral steroid | 0 | 0 | 1 | 1 | 4 | 6 |
DMARD | 0 | 0 | 2 | 1 | 0 | 0 |
Parenteral steroid + DMARD | 2 | 1 | 2 | 2 | 0 | 0 |
Treatment received prior to follow-up joint aspiration where no more apoptosis was seen at follow-up | ||||||
Nil | 2 | 0 | 0 | 0 | 3 | 2 |
Parenteral steroid | 1 | 0 | 4 | 6 | 4 | 4 |
DMARD | 0 | 0 | 0 | 0 | 0 | 0 |
Parenteral steroid + DMARD | 5 | 5 | 1 | 1 | 0 | 0 |