Table 2 Major interleukin-10 (IL-10)-induced transcripts in monocytes from patients with rheumatoid arthritis
Symbol | Encoded protein | Gene name | IL-10-induced changes (folds) | |
|---|---|---|---|---|
| Â | Â | Â | Patient 1 | Patient 2 |
BMPR1A | Bone morphogenetic protein receptor, type IA | ALK-3 | 2.41 | 2.37 |
BMPR1B | Bone morphogenetic protein receptor, type IB | ALK-6 | 0.74 | 9.79 |
BMPR2 | Bone morphogenetic protein receptor, type II | BMPR-II | 1.81 | 1.32 |
CCL15 | Chemokine (C-C motif) ligand 15 | MIP-1 delta/MIP-5 | 1.84 | 1.07 |
CCR5 | Chemokine (C-C motif) receptor 5 | CCR5 | 1.93 | 1.11 |
CXCL3 | Chemokine (C-X-C motif) ligand 3 | GRO3 | 2.17 | 0.83 |
IRAK2 | Interleukin-1 receptor-associated kinase 2 | IRAK2 | 1.93 | 2.73 |
SOCS3 | Suppressor of cytokine signaling 3 | SSI-3 | 3.84 | 15.29 |
TGFBR2 | Transforming growth factor, β receptor II | TGFBR2 | 2.17 | 0.79 |
TGFBR3 | Transforming growth factor, β receptor III | TGFBR3 | 2.04 | 0.29 |
TIMP1 | Tissue inhibitor of metalloproteinase 1 | TIMP1 | 3.49 | 1.46 |
TLR2 | Homo sapiens Toll-like receptor 2 | TLR2 | 1.38 | 2.28 |
TLR3 | Homo sapiens Toll-like receptor 3 | TLR3 | 3.03 | 16.61 |
TLR4 | Homo sapiens Toll-like receptor 4 | TLR4 | 2.66 | 1.86 |
TLR9 | Homo sapiens Toll-like receptor 9 | TLR9 | 2.44 | 0.78 |
TLR10 | Homo sapiens Toll-like receptor 10 | TLR10 | 2.78 | 0.90 |
TNFRSF1B | Tumour necrosis factor receptor superfamily, member 1B | TNFR2/p75 | 2.64 | 0.91 |
TNFRSF7 | Tumour necrosis factor receptor superfamily, member 7 | CD27 | 8.99 | 0.57 |
TNFRSF8 | Tumour necrosis factor receptor superfamily, member 8 | CD30 | 3.13 | 1.15 |
TNFSF11 | Tumour necrosis factor (ligand) superfamily, member 11 | TRANCE | 3.50 | 2.01 |
TNFRSF11A | Tumour necrosis factor receptor superfamily, member 11a, activator of nuclear factor-κB | Rank | 2.50 | 0.56 |
TNFSF4 | Tumour necrosis factor (ligand) superfamily, member 4 | OX40L | 2.67 | 1.06 |
TRAF4 | TNF receptor-associated factor 4 | TRAF4 | 2.18 | 1.00 |
TRAF6 | TNF receptor-associated factor 6 | TRAF6 | 3.49 | 0.56 |
PUC18 | PUC18 plasmid DNA | pUC18 | 0.00 | 0.00 |
ACTB | β-actin | β-actin | 0.92 | 0.91 |