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Study population
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1.
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Patients with radiographically confirmed osteoarthritis or selected according to American College of Rheumatology guidelines
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2.
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Age, gender, and body mass index reported and not statistically different between groups
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3.
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Efficacy assessed on a single anatomical joint (for example, knee)
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Trial design
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4.
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Randomisation
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5.
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Placebo-controlled study
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6.
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Double-blind study
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7.
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Duration of at least 3 months
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8.
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Selection of a single primary endpoint before beginning of trial
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9.
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Sample size based on power calculation
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Analysis and data presentation
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10.
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Data analysed according to the intention-to-treat principle
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11.
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Reported dropout rate not more than 25%
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12.
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Report of adverse effects
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