Nutritional intervention Trial (Author's name/year) [reference number] | Was treatment efficient? | OA score | Jadad score of the RCT | Global score of the functional ingredients | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Criterion number | Totalscore of the RCT |  |  | |||||||||||
 |  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |  |  |  |
Avocado soybean unsaponifiables | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 1.58 |
Blotman 1997 [24] | Yes | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.92 | 5 | Â |
Maheu 1998 [26] | Yes | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | Â |
Appelboom 2001 [25] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0.83 | 3 | Â |
Lequesne 2002 [27]b | No | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | -0.92 | 5 | -0.92 |
Methylsulfonylmethane | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 1.21 |
Usha 2004 [130] | Yes | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0.92 | 5 | Â |
Kim 2006 [131] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0.83 | 5 | Â |
SKI306X | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 1.12 |
Jung 2001 [125] | Yes | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0.83 | 4 | Â |
Jung 2004 [126] | Yes | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0.75 | 5 | Â |
Vitamin B 3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.75 |
Jonas 1996 [79] | Yes | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0.75 | 5 | Â |
Vitamin C | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.75 |
Jensen 2003 [58] | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0.75 | 5 | Â |
Duhuo Jisheng Wan | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.67 |
Teekachunhatean 2004 [129] | Yes | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0.67 | 3 | Â |
Lipids from Perna canaliculus | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.58 |
Gibson 1980 [46] | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0.58 | 4 | Â |
Audeval 1986 [45] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0.75 | 4 | Â |
Gibson 1998 [47] | Yes | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0.42 | 5 | Â |
Cetyl myristoleate | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.58 |
Hesslink 2002 [50] | Yes | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0.58 | 3 | Â |
Harpagophytum procumbens | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.54 |
Lecomte 1992 [99] | Yes | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.33 | 3 | Â |
Chantre 2000 [100] | Yes | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.75 | 5 | Â |
Bromelain | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.53 |
Singer 1996 [92] | Yes | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0.58 | 4 | Â |
Klein 2000 [91] | Yes | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0.58 | 4 | Â |
Singer 2001 [142] | Yes | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0.58 | 4 | Â |
Tilwe 2001 [89] | Yes | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0.33 | 2 | Â |
Akhtar 2004 [90] | Yes | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0.58 | 4 | Â |
Boron | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.50 |
Newnham 1994 [85] | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0.50 | 4 | Â |
Uncaria guianensis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.50 |
Piscoya 2001 [106] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.50 | 3 | Â |
Boswellia serrata | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.48 |
Kulkarni 1991 [123]c | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0.50 | 3 | Â |
Badria 2003 [122] | Yes | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0.42 | 3 | Â |
Kimmatkar 2003 [121] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0.50 | 5 | Â |
Ginger | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.42 |
Bliddal 2000 [115] | No | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | -0.58 | 5 | Â |
Altman 2001 [113] | Yes | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0.75 | 3 | Â |
Wigler 2003 [112] | Yes | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0.67 | 5 | Â |
Vitamin E | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.17 |
Machtey 1978 [71] | Yes | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0.50 | 1 | Â |
Blankenhorn 1986 [72] | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0.50 | 4 | Â |
Scherak 1990 [73] | Yes | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0.42 | 3 | Â |
Brand 2001 [74] | No | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | -0.92 | 5 | Â |
Wluka 2002 [75]b | No | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | -0.92 | 5 | -0.92 |
'Hyperimmune' milk | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | -0.09 |
Colker 2002 [134] | No | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | -0.67 | 4 | Â |
Zenk 2002 [135] | Yes | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0.50 | 5 | Â |
Collagen hydrolysate | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | -0.17 |
Adam 1991 [138] | Yes | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.33 | 3 | Â |
Moskowitz 2000 [137] | No | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | -0.67 | 3 | Â |
Salix sp . | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | -0.25 |
Mills 1996 [110]d | No | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | -0.42 | 5 | Â |
Schmid 2001 [108] | Yes | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0.75 | 5 | Â |
Biegert 2004 [109] | No | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | -0.83 | 5 | Â |