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Table 3 Ingredients, with the scores of the trialsa, displayed by decreasing order of strength of evidence

From: Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence

Nutritional intervention Trial (Author's name/year) [reference number] Was treatment efficient? OA score Jadad score of the RCT Global score of the functional ingredients
   Criterion number Totalscore of the RCT   
   1 2 3 4 5 6 7 8 9 10 11 12    
Avocado soybean unsaponifiables                 1.58
Blotman 1997 [24] Yes 1 1 0 1 1 1 1 1 1 1 1 1 0.92 5  
Maheu 1998 [26] Yes 1 1 1 1 1 1 1 1 1 1 1 1 1 5  
Appelboom 2001 [25] Yes 1 0 1 1 1 1 1 1 0 1 1 1 0.83 3  
Lequesne 2002 [27]b No 1 1 1 1 1 1 1 1 1 1 0 1 -0.92 5 -0.92
Methylsulfonylmethane                 1.21
Usha 2004 [130] Yes 1 1 1 1 1 1 1 0 1 1 1 1 0.92 5  
Kim 2006 [131] Yes 1 0 1 1 1 1 1 0 1 1 1 1 0.83 5  
SKI306X                 1.12
Jung 2001 [125] Yes 1 1 1 1 1 1 0 1 1 1 0 1 0.83 4  
Jung 2004 [126] Yes 1 0 1 1 0 1 0 1 1 1 1 1 0.75 5  
Vitamin B 3                 0.75
Jonas 1996 [79] Yes 1 1 0 1 1 1 1 0 1 0 1 1 0.75 5  
Vitamin C                 0.75
Jensen 2003 [58] Yes 1 0 0 1 1 1 0 1 1 1 1 1 0.75 5  
Duhuo Jisheng Wan                 0.67
Teekachunhatean 2004 [129] Yes 1 1 1 1 0 1 0 0 0 1 1 1 0.67 3  
Lipids from Perna canaliculus                 0.58
Gibson 1980 [46] Yes 1 0 0 1 1 1 1 0 0 0 1 1 0.58 4  
Audeval 1986 [45] Yes 1 0 1 1 1 1 1 1 0 0 1 1 0.75 4  
Gibson 1998 [47] Yes 1 0 0 1 0 1 1 0 0 0 1 0 0.42 5  
Cetyl myristoleate                 0.58
Hesslink 2002 [50] Yes 1 1 1 1 1 1 0 0 0 0 1 0 0.58 3  
Harpagophytum procumbens                 0.54
Lecomte 1992 [99] Yes 0 0 0 1 1 1 0 0 0 0 0 1 0.33 3  
Chantre 2000 [100] Yes 1 0 0 1 0 1 1 1 1 1 1 1 0.75 5  
Bromelain                 0.53
Singer 1996 [92] Yes 1 0 1 1 0 1 0 0 0 1 1 1 0.58 4  
Klein 2000 [91] Yes 1 0 1 1 0 1 0 1 0 1 1 0 0.58 4  
Singer 2001 [142] Yes 1 0 1 1 0 1 0 0 0 1 1 1 0.58 4  
Tilwe 2001 [89] Yes 1 0 1 1 0 0 0 0 0 1 0 0 0.33 2  
Akhtar 2004 [90] Yes 1 1 1 1 0 1 0 0 0 1 0 1 0.58 4  
Boron                 0.50
Newnham 1994 [85] Yes 1 0 0 1 1 1 0 0 0 0 1 1 0.50 4  
Uncaria guianensis                 0.50
Piscoya 2001 [106] Yes 1 0 1 1 1 1 0 0 0 0 0 1 0.50 3  
Boswellia serrata                 0.48
Kulkarni 1991 [123]c Yes 1 0 0 1 1 1 1 0 0 0 0 1 0.50 3  
Badria 2003 [122] Yes 0 0 1 1 1 1 1 0 0 0 0 0 0.42 3  
Kimmatkar 2003 [121] Yes 1 0 1 1 1 1 0 0 0 0 1 0 0.50 5  
Ginger                 0.42
Bliddal 2000 [115] No 1 0 0 1 1 1 0 0 1 0 1 1 -0.58 5  
Altman 2001 [113] Yes 1 1 1 1 1 0 0 1 0 1 1 1 0.75 3  
Wigler 2003 [112] Yes 1 0 1 1 1 1 1 0 0 1 0 1 0.67 5  
Vitamin E                 0.17
Machtey 1978 [71] Yes 1 0 0 1 1 0 0 1 0 0 1 1 0.50 1  
Blankenhorn 1986 [72] Yes 1 0 0 1 1 1 0 0 0 0 1 1 0.50 4  
Scherak 1990 [73] Yes 1 0 0 1 0 1 0 0 0 0 1 1 0.42 3  
Brand 2001 [74] No 1 0 1 1 1 1 1 1 1 1 1 1 -0.92 5  
Wluka 2002 [75]b No 1 1 1 1 1 1 1 1 1 1 1 0 -0.92 5 -0.92
'Hyperimmune' milk                 -0.09
Colker 2002 [134] No 0 1 1 1 1 1 0 1 0 0 1 1 -0.67 4  
Zenk 2002 [135] Yes 0 1 0 1 0 1 0 1 0 0 1 1 0.50 5  
Collagen hydrolysate                 -0.17
Adam 1991 [138] Yes 1 0 0 1 1 1 0 0 0 0 0 0 0.33 3  
Moskowitz 2000 [137] No 1 0 1 1 1 1 1 0 0 1 0 1 -0.67 3  
Salix sp .                 -0.25
Mills 1996 [110]d No 0 0 0 1 1 1 0 0 0 0 1 1 -0.42 5  
Schmid 2001 [108] Yes 1 1 0 1 1 1 0 1 0 1 1 1 0.75 5  
Biegert 2004 [109] No 1 1 0 1 1 1 0 1 1 1 1 1 -0.83 5  
  1. Each item of the osteoarthritis (OA) score was given 1 point when it met the specified criterion listed in Table 2. If it did not meet the criterion or was not described at all, a score of 0 was assigned. For each trial, the sum of the individual scores was expressed as a percentage to give a relative total quality score. aTo be included in this table, any functional ingredient had to have its efficacy supported at least by one trial. This was considered to be the case when a statistical difference in the primary endpoint of a clinical trial was observed or, in the absence of a defined primary endpoint, when statistical differences were observed in several of the reported endpoints. bRandomised human clinical trial (RCT) evaluating the structure-modifying effects of the functional ingredients. cCocktail of three plant extracts and zinc complex.dCocktail of five plant extracts among which one extract from Salix sp.