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Table 2 Radiographic damage among patients with two, one, or no copies of SE alleles stratified according to RF and anti-CCP status

From: Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis

Antibody status Number of SE alleles n Larsen's score (mean ± SEM) P (SE2 versus SE1 versus SE0)
All 2 266 46.5 ± 2.3 NS
  1 393 43.6 ± 1.9  
  0 168 39.2 ± 2.6  
RF positive 2 177 49.5 ± 2.9 NS
  1 253 49.4 ± 2.5  
  0 94 47.0 ± 3.7  
RF negative 2 71 39.0 ± 4.3 0.0458a
  1 120 32.3 ± 2.7  
  0 65 25.9 ± 3.1  
CCP positive 2 226 49.1 ± 2.5 NS
  1 312 45.7 ± 2.1  
  0 98 44.3 ± 3.4  
CCP negative 2 30 32.0 ± 5.9 NS
  1 67 32.3 ± 3.7  
  0 58 29.2 ± 3.9  
  1. Shown is an analysis of radiographic damage among patients with 2 (SE2), 1 (SE1) or no (SE0) copies of SE alleles stratified according to RF and anti-CCP (shortened to CCP) status. aBy analysis of variance. anti-CCP, anti-cyclic citrullinated peptide antibody; NS, not significant; RF, rheumatoid factor; SEM, standard error of the mean.