Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis

Table 2 Radiographic damage among patients with two, one, or no copies of SE alleles stratified according to RF and anti-CCP status

Antibody status	Number of SE alleles	n	Larsen's score (mean ± SEM)	P (SE2 versus SE1 versus SE0)
All	2	266	46.5 ± 2.3	NS
	1	393	43.6 ± 1.9
	0	168	39.2 ± 2.6
RF positive	2	177	49.5 ± 2.9	NS
	1	253	49.4 ± 2.5
	0	94	47.0 ± 3.7
RF negative	2	71	39.0 ± 4.3	0.0458^a
	1	120	32.3 ± 2.7
	0	65	25.9 ± 3.1
CCP positive	2	226	49.1 ± 2.5	NS
	1	312	45.7 ± 2.1
	0	98	44.3 ± 3.4
CCP negative	2	30	32.0 ± 5.9	NS
	1	67	32.3 ± 3.7
	0	58	29.2 ± 3.9

Shown is an analysis of radiographic damage among patients with 2 (SE2), 1 (SE1) or no (SE0) copies of SE alleles stratified according to RF and anti-CCP (shortened to CCP) status. ^aBy analysis of variance. anti-CCP, anti-cyclic citrullinated peptide antibody; NS, not significant; RF, rheumatoid factor; SEM, standard error of the mean.

ISSN: 1478-6362