TY - JOUR AU - Kinderlerer, Anne R. AU - Steinberg, Rivka AU - Johns, Michael AU - Harten, Sarah K. AU - Lidington, Elaine A. AU - Haskard, Dorian O. AU - Maxwell, Patrick H. AU - Mason, Justin C. PY - 2006 DA - 2006/07/21 TI - Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis JO - Arthritis Research & Therapy SP - R130 VL - 8 IS - 4 AB - Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported that statins have anti-inflammatory effects in RA. We hypothesized that the anti-inflammatory effect of statins in RA relates in part to their ability to increase CD59 expression in hypoxic conditions and therefore to reduce complement activation. SN - 1478-6354 UR - https://doi.org/10.1186/ar2019 DO - 10.1186/ar2019 ID - Kinderlerer2006 ER -