Predictors of infusion reactions during infliximab treatment in patients with arthritis

Table 3 Positive predictive values for separate factors and combination of presence of ANAs and methotrexate treatment for development of infusion reactions in RA patients

Factors	Patients (n)	OR	95% CI	P
ANA positivity	56	2.1	1.04–4.29	0.040^a
Infliximab without methotrexate	84	3.1	1.53–6.29	0.002^a
Infliximab as monotherapy	46	3.6	1.73–7.14	0.001^a
ANA positive + MTX no	26	4.6	1.61–13.15	0.004^b
ANA positive + MTX yes	30	2.2	0.74–6.36	0.161^b
ANA negative + MTX yes	93	1.0	-	-
ANA negative + MTX no	52	3.3	1.35–8.06	0.009^b

^aAdjusted for age, sex and prednisolone at start. ^bAdjusted for age, sex and disease duration. ANA, antinuclear antibody; CI, confidence interval; MTX, methotrexate; OR, odds ratio; RA, rheumatoid arthritis.

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