| Women | Men | Both genders | ||
---|---|---|---|---|---|
 | Number of patients/controls | ORa (95% CI) | Number of patients/controls | ORa (95% CI) | ORa (95% CI) |
Smoker status | Â | Â | Â | Â | Â |
   Never | 128/223 | 1 (ref) | 26/75 | 1 (ref) | 1 (ref) |
   Former | 68/76 | 1.69 (1.12 to 2.55) | 40/79 | 1.58 (0.84 to 2.97) | 1.57 (1.13 to 2.19) |
   Current | 170/179 | 1.84 (1.33 to 2.54) | 83/137 | 1.89 (1.09 to 3.30) | 1.80 (1.37 to 2.36) |
   Test for homogeneity (p) |  | <0.001 |  | 0.08 | < 0.001 |
Pack-years smoked b | Â | Â | Â | Â | Â |
   0 pack-years | 128/223 | 1 (ref) | 26/75 | 1 (ref) | 1 (ref) |
   >0 to 10 pack-years | 77/100 | 1.54 (1.04 to 2.28) | 21/42 | 1.42 (0.69 to 2.91) | 1.44 (1.02 to 2.02) |
   >10 to 20 pack-years | 78/81 | 1.84 (1.23 to 2.77) | 25/44 | 1.86 (0.92 to 3.77) | 1.84 (1.30 to 2.59) |
   >20 pack-years | 78/70 | 2.07 (1.35 to 3.16) | 76/126 | 2.00 (1.12 to 3.58) | 1.93 (1.40 to 2.68) |
   Trend test (p) |  | <0.001 |  | 0.03 | <0.001 |
Coffee consumption c | Â | Â | Â | Â | Â |
   0 cups per day | 70/116 | 1 (ref) | 14/26 | 1 (ref) | 1 (ref) |
   >0 to 5 cups per day | 148/219 | 1.16 (0.76 to 1.79) | 42/107 | 0.79 (0.35 to 1.81) | 1.12 (0.77 to 1.64) |
   >5 to 10 cups per day | 117/122 | 1.68 (1.05 to 2.70) | 60/112 | 1.09 (0.49 to 2.46) | 1.59 (1.07 to 2.38) |
   >10 cups per day | 30/20 | 2.88 (1.43 to 5.79) | 33/45 | 1.57 (0.64 to 3.84) | 2.33 (1.40 to 3.87) |
   Trend test (p) |  | <0.001 |  | 0.05 | <0.001 |
Alcohol consumption c,d | Â | Â | Â | Â | Â |
   0 drinks per week | 79/80 | 1.36 (0.91 to 2.03) | 11/13 | 1.38 (0.51 to 3.72) | 1.34 (0.93 to 1.93) |
   >0 to 5 drinks per week | 170/227 | 1 (ref) | 42/75 | 1 (ref) | 1 (ref) |
   >5 to 10 drinks per week | 68/109 | 0.87 (0.60 to 1.27) | 35/54 | 1.24 (0.68 to 2.26) | 0.95 (0.70 to 1.30) |
   >10 to 15 drinks per week | 29/34 | 1.21 (0.69 to 2.11) | 11/41 | 0.42 (0.19 to 0.94) | 0.80 (0.52 to 1.24) |
   >15 drinks per week | 15/26 | 0.74 (0.37 to 1.47) | 47/104 | 0.82 (0.47 to 1.43) | 0.79 (0.53 to 1.17) |
   Trend test (p) |  | 0.21 |  | 0.20 | 0.05 |
Wine consumption c | Â | Â | Â | Â | Â |
   0 glasses per week | 120/135 | 1.23 (0.89 to 1.71) | 36/65 | 0.89 (0.52 to 1.52) | 1.09 (0.83 to 1.44) |
   >0 to 5 glasses per week | 191/251 | 1 (ref) | 87/139 | 1 (ref) | 1 (ref) |
   >5 to 10 glasses per week | 34/67 | 0.62 (0.39 to 1.00) | 18/57 | 0.48 (0.26 to 0.89) | 0.57 (0.39 to 0.83) |
   >10 to 15 glasses per week | 11/16 | 0.82 (0.36 to 1.86) | 2/17 | 0.15 (0.03 to 0.70) | 0.53 (0.27 to 1.04) |
   >15 glasses per week | 6/8 | 0.96 (0.31 to 2.92) | 6/11 | 1.05 (0.35 to 3.09) | 0.95 (0.44 to 2.02) |
   Trend test (p) |  | 0.10 |  | 0.08 | 0.02 |
Body mass index c | Â | Â | Â | Â | Â |
   <18.5 kg/m2 (underweight) | 25/36 | 0.95 (0.52 to 1.73) | 3/5 | 0.95 (0.19 to 4.72) | 0.90 (0.52 to 1.56) |
   18.5 to < 25 kg/m2 (normal weight) | 232/327 | 1 (ref) | 73/137 | 1 (ref) | 1 (ref) |
   25 to < 30 kg/m2 (overweight) | 73/80 | 1.26 (0.87 to 1.85) | 52/116 | 0.86 (0.54 to 1.37) | 1.05 (0.79 to 1.40) |
   ≥ 30 kg/m2 (obese) | 26/21 | 1.83 (0.97 to 3.44) | 21/30 | 1.39 (0.71 to 2.71) | 1.57 (1.01 to 2.44) |
   Trend test (p) |  | 0.04 |  | 0.57 | 0.07 |
Body mass index at age 20 | Â | Â | Â | Â | Â |
   <18.5 kg/m2 (underweight) | 56/62 | 1.39 (0.92 to 2.10) | 4/9 | 0.75 (0.21 to 2.73) | 1.29 (0.88 to 1.89) |
   18.5 to <25 kg/m2 (normal weight) | 258/371 | 1 (ref) | 108/220 | 1 (ref) | 1 (ref) |
   25 to <30 kg/m2 (overweight) | 36/30 | 1.72 (1.01 to 2.92) | 28/38 | 1.65 (0.93 to 2.93) | 1.61 (1.10 to 2.34) |
   ≥ 30 kg/m2 (obese) | 4/6 | 1.33 (0.35 to 5.09) | 5/5 | 1.92 (0.50 to 7.38) | 1.59 (0.63 to 4.00) |
   Trend test (p) |  | 0.64 |  | 0.05 | 0.15 |
Physical activity at work c | Â | Â | Â | Â | Â |
   Not physically demanding | 46/94 | 1 (ref) | 23/59 | 1 (ref) | 1 (ref) |
   Slightly physically demanding | 80/104 | 1.53 (0.95 to 2.47) | 37/73 | 1.25 (0.65 to 2.41) | 1.47 (1.01 to 2.14) |
   Moderately physically demanding | 91/106 | 1.70 (1.07 to 2.72) | 47/85 | 1.41 (0.75 to 2.67) | 1.64 (1.13 to 2.37) |
   Very physically demanding | 85/94 | 1.84 (1.14 to 2.96) | 35/58 | 1.62 (0.82 to 3.18) | 1.73 (1.18 to 2.53) |
   Unemployed | 63/80 | 1.68 (0.95 to 2.98) | 7/16 | 0.94 (0.30 to 2.93) | 1.48 (0.91 to 2.42) |
   Trend test (p)e,f |  | 0.01 |  | 0.11 | 0.005 |
Physical activity in leisure time c | Â | Â | Â | Â | Â |
   Not physically demanding | 28/28 | 1 (ref) | 25/29 | 1 (ref) | 1 (ref) |
   Slightly physically demanding | 125/150 | 0.80 (0.44 to 1.45) | 52/76 | 0.84 (0.42 to 1.66) | 0.77 (0.50 to 1.19) |
   Moderately physically demanding | 180/260 | 0.65 (0.37 to 1.16) | 59/145 | 0.44 (0.23 to 0.84) | 0.56 (0.37 to 0.86) |
   Very physically demanding | 33/39 | 0.92 (0.44 to 1.94) | 13/41 | 0.26 (0.10 to 0.65) | 0.61 (0.35 to 1.05) |
   Trend test (p)e |  | 0.35 |  | <0.001 | 0.004 |
Pets as adult | Â | Â | Â | Â | Â |
   Never | 68/51 | 1 (ref) | 22/36 | 1 (ref) | 1 (ref) |
   Ever | 298/427 | 0.46 (0.30 to 0.71) | 127/255 | 0.85 (0.46 to 1.58) | 0.56 (0.40 to 0.79) |
   Test for homogeneity (p) |  | <0.001 |  | 0.61 | <0.001 |