Figure 6
From: Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously
Total and type II collagen-specific IgG levels in DQ6α8β transgenic expressing mice. Sera samples from (a) 10 middle-aged mice with spontaneous polychondritis, (b) from 10 young mice with type II collagen (CII)-induced polychondritis, (c) from 10 young naïve mice not displaying clinical disease or (d) from 10 middle-aged mice not displaying clinical disease were collected and assessed for the levels of total IgG and CII-specific IgG by ELISA. Polychondritic mice had greatly elevated levels of total IgG, but only CII-induced polychondritic mice had elevated CII-specific IgG. OD, optical density.