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Table 2 Renal clearance of creatinine and NOx, and fractional excretion of NOx

From: Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures

Measure

Group

n

Median (interquartile range)

p

Creatinine clearance (ml/min)

Normal

20

84 (74–97)

NS (0.071)

 

RA

25

99 (82–133)

 

NOx clearance (ml/min), 0–24 h

Normal

17

125(72–209)

0.004

 

RA

23

31 (16–73)

 

NOx clearance (ml/min), 24–48 h

Normal

17

69 (38–106)

0.026

 

RA

23

38 (20–58)

 

NOx clearance (ml/min), 48–72 h

Normal

17

47 (20–80)

0.014

 

RA

23

27 (11–34)

 

NOx fractional excretion, 0–24 h

Normal

17

1.40 (0.78–2.26)

0.004

 

RA

23

0.35 (0.19–0.82)

 

NOx fractional excretion, 24–48 h

Normal

17

0.81 (0.48–1.23)

0.010

 

RA)

23

0.29 (0.17–0.71)

 

NOx fractional excretion, 48–72 h

Normal

17

0.56 (0.16–0.94)

0.010

 

RA

23

0.28 (0.11–0.38)

 
  1. NOx, nitrite + nitrate; NS, not significant (comparing normal and RA); RA, rheumatoid arthritis.