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Table 1 Joint pathology score

From: Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine

Group

Score

Mean ± SEM

P value

Control dendritic cells

3, 3, 4, 3, 3.5, 3

3.250 ± 0.171

 

LF 15-0195-treated dendritic cells

1, 0, 1.5, 1, 1.5, 1

1.000 ± 0.224

0.000283

  1. Histopathologic changes are scored using the following parameters. Synovial inflammation (infiltration and hyperplasia) is scored on a scale from 0 to 4, depending on the amount of inflammatory cells in the synovial cavity (exudates) and synovial tissues (infiltrate). Each joint is scored separately by two individuals unaware of the treatment protocol, using the following scale: no inflammation = 0; slight thickening of lining layer and/or some infiltrating cells in the sublining layer = 1–2; thickening of lining layer and/or a more pronounced influx of cells in the sublining layer = 3; and presence of cells in the synovial space, thickening of lining layer, and synovium highly infiltrated with numerous inflammatory cells = 4.
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Arthritis Research & Therapy

ISSN: 1478-6362

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