Figure 3
From: Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice
Co-immunization of DR4 transgenic mice with type II collagen and analog peptides. Groups of DR4 transgenic mice were co-immunized with 50 μg of type II collagen (CII) alone (n = 18; circles) or with 50 μg of CII plus 1.2 mg of the analog peptide CI256–276, (F263N, E266D) (n = 16; upward triangles), with 50 μg of CII plus 1.2 mg of the analog peptide CII256–276 (F263N, E266A) (n = 10; downward triangles), or with 50 μg of CII plus 1.2 mg of the analog peptide CII256–276 (E266D) (n = 10; diamonds) and observed for arthritis. Results are incidences (upper panel) and mean severity scores (lower panel) of arthritis observed at various time points after immunization.