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Table 3 Odds ratios for cardiovascular disease

From: Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study

Groups Model 1 OR (95 percent CI) Model 2 OR (95 percent CI) Model 3 OR (95 percent CI)
Never MTX, SSZ or HCQ (reference) 1.0 1.0 1.0
Only MTX ever 0.16 (0.04–0.66)a 0.47 (0.07–3.23) 0.11 (0.02–0.56)a
Only SSZ ever 0.42 (0.16–1.10) 0.31 (0.07–1.33) 0.37 (0.14–0.99)a
Only HCQ ever 0.55 (0.18–1.67) 0.45 (0.10–2.04) 0.47 (0.15–1.46)
MTX and SSZ ever 0.20 (0.08–0.51)a 0.24 (0.07–0.85)a 0.16 (0.06–0.42)a
MTX and HCQ ever 0.22 (0.04–1.19) 0.54 (0.08–3.66) 0.19 (0.04–1.02)
SSZ and HCQ ever 0.44 (0.14–1.41) 0.34 (0.05–2.16) 0.37 (0.11–1.24)
MTX, SSZ and HCQ ever 0.20 (0.08–0.54)a 0.27 (0.07–0.99)a 0.16 (0.06–0.43)a
  1. Model 1: correcting for age, gender, smoking and rheumatoid arthritis duration. Model 2: identical to 'Model 1' plus correction for hypertension, diabetes and hypercholesterolemia. Model 3: identical to 'Model 1' plus correction for a positive rheumatoid factor test and erosions. aSignificant. CI, confidence interval; HCQ, hydroxychloroquine; MTX, methotrexate; OR, odds ratio; SSZ, sulfasalazine.