Figure 1

Computer model of differentially expressed genes in juvenile rheumatoid arthritis and control neutrophils developed from PathwayAssist software as described in Materials and methods. Note upregulation of S100 proteins in patients (top left). Also note clusters of genes independently or interdependently regulated by interleukin-8 or interferon-γ (blue circles, bottom left and right). Finally, computer modeling showed significant associations between differentially expressed genes and the regulation of fundamental metabolic processes such as H₂O₂ production (multiple green circles) and calcium influx (top left).