Table 1 Genes over-expressed in JRA neutrophils
GenBank accession no. | Symbol | Description | Avg. control | Avg. patients | Ratio P/C |
|---|---|---|---|---|---|
NM_001124 | ADM | Adrenomedullin | 0.3 | 3.2 | 10.3 |
NM_001706 | BCL6 | B-cell CLL/lymphoma 6 (zinc finger protein 51) | 54.0 | 179.9 | 3.3 |
NM_001729 | BTC | Betacellulin | 0.2 | 2.8 | 12.1 |
NM_001295 | CCR1 | Chemokine (C-C motif) receptor 1 | 1.5 | 5.6 | 3.7 |
NM_001785 | CDA | Cytidine deaminase | 10.9 | 30.6 | 2.8 |
NM_004360 | CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | 0.3 | 2.2 | 6.4 |
NM_005194 | CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 1.1 | 3.7 | 3.2 |
NM_000651 | CR1 | Complement component (3b/4b) receptor 1, including Knops blood group system | 6.6 | 21.3 | 3.2 |
AF172398 | F11R | F11 receptor, JAM1 | 0.5 | 3.5 | 7.2 |
NM_002005 | FES | Feline sarcoma oncogene | 35.6 | 108.3 | 3.0 |
NM_001462 | FPRL1 | Formyl peptide receptor-like 1 | 21.0 | 72.0 | 3.4 |
NM_000637 | GSR | Glutathione reductase | 3.7 | 18.5 | 5.0 |
NM_015401 | HDAC7A | Histone deacetylase 7A | 3.3 | 9.7 | 2.9 |
NM_002127 | HLA-G | HLA-G histocompatibility antigen, class I, G | 336.2 | 956.2 | 2.8 |
NM_005345 | HSPA1A | Heat shock 70-kDa protein 1A | 20.6 | 53.7 | 2.6 |
NM_014339 | IL17R | Interleukin 17 receptor | 10.2 | 28.5 | 2.8 |
NM_000634 | IL8RA | Interleukin 8 receptor, alpha | 13.6 | 53.9 | 4.0 |
BC017197 | MCL1 | Myeloid cell leukemia sequence 1 (BCL2-related) | 5.3 | 21.5 | 4.1 |
NM_007289 | MME | Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) | 9.5 | 29.5 | 3.1 |
NM_013416 | NCF4 | Neutrophil cytosolic factor 4 (40 kDa) | 20.0 | 58.6 | 2.9 |
AF171938 | NUMB | Numb homolog (Drosophila) | 3.2 | 11.6 | 3.7 |
NM_023914 | P2RY13 | purinergic receptor P2Y, G-protein coupled, 13, GPR86 | 8.7 | 32.0 | 3.7 |
NM_014143 | PDCD1LG1 | programmed cell death 1 ligand, B7-H1 | 0.3 | 5.1 | 15.3 |
NM_000442 | PECAM1 | Platelet/endothelial cell adhesion molecule (CD31 antigen) | 6.2 | 12.5 | 2.0 |
NM_001198 | PRDM1 | PR domain containing 1, with ZNF domain | 0.8 | 6.8 | 8.9 |
NM_000962 | PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.3 | 8.6 | 29.5 |
NM_002838 | PTPRC | Protein tyrosine phosphatase, receptor type, C | 55.9 | 159.7 | 2.9 |
NM_002881 | RALB | V-ral simian leukemia viral oncogene homolog B (ras related-GTP binding protein) | 5.2 | 15.8 | 3.0 |
NM_004761 | RGL2 | ral guanine nucleotide dissociation stimulator-like 2, RAB2 | 3.0 | 8.9 | 3.0 |
NM_005621 | S100A12 | S100 calcium binding protein A12 (calgranulin C) | 62.9 | 164.0 | 2.6 |
NM_002964 | S100A8 | S100 calcium binding protein A8 (calgranulin A) | 791.4 | 2,017.6 | 2.5 |
NM_002965 | S100A9 | S100 calcium binding protein A9 (calgranulin B) | 1,152.7 | 2,697.1 | 2.3 |
D83782 | SCAP | SREBP CLEAVAGE-ACTIVATING PROTEIN | 0.3 | 2.6 | 7.5 |
NM_022464 | SIL1 | Endoplasmic reticulum chaperone SIL1, homolog of yeast | 0.3 | 5.0 | 14.9 |
NM_004171 | SLC1A2 | Solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 7.5 | 32.9 | 4.4 |
NM_001045 | SLC6A4 | Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 22.8 | 44.5 | 2.0 |
NM_003105 | SORL1 | Sortilin-related receptor, L(DLR class) A repeats-containing | 31.9 | 89.7 | 2.8 |
NM_003153 | STAT6 | Signal transducer and activator of transcription 6, interleukin-4 induced | 1.6 | 7.9 | 5.0 |
NM_003263 | TLR1 | Toll-like receptor 1 | 10.4 | 28.6 | 2.8 |
NM_003841 | TNFRSF10C | Tumour necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 8.9 | 39.6 | 4.5 |
NM_006573 | TNFSF13B | Tumour necrosis factor (ligand) superfamily, member 13b | 9.2 | 22.4 | 2.4 |
NM_003329 | TXN | Thioredoxin | 9.0 | 24.8 | 2.8 |