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Table 1 Genes over-expressed in JRA neutrophils

From: Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis

GenBank accession no. Symbol Description Avg. control Avg. patients Ratio P/C
NM_001124 ADM Adrenomedullin 0.3 3.2 10.3
NM_001706 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) 54.0 179.9 3.3
NM_001729 BTC Betacellulin 0.2 2.8 12.1
NM_001295 CCR1 Chemokine (C-C motif) receptor 1 1.5 5.6 3.7
NM_001785 CDA Cytidine deaminase 10.9 30.6 2.8
NM_004360 CDH1 Cadherin 1, type 1, E-cadherin (epithelial) 0.3 2.2 6.4
NM_005194 CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.1 3.7 3.2
NM_000651 CR1 Complement component (3b/4b) receptor 1, including Knops blood group system 6.6 21.3 3.2
AF172398 F11R F11 receptor, JAM1 0.5 3.5 7.2
NM_002005 FES Feline sarcoma oncogene 35.6 108.3 3.0
NM_001462 FPRL1 Formyl peptide receptor-like 1 21.0 72.0 3.4
NM_000637 GSR Glutathione reductase 3.7 18.5 5.0
NM_015401 HDAC7A Histone deacetylase 7A 3.3 9.7 2.9
NM_002127 HLA-G HLA-G histocompatibility antigen, class I, G 336.2 956.2 2.8
NM_005345 HSPA1A Heat shock 70-kDa protein 1A 20.6 53.7 2.6
NM_014339 IL17R Interleukin 17 receptor 10.2 28.5 2.8
NM_000634 IL8RA Interleukin 8 receptor, alpha 13.6 53.9 4.0
BC017197 MCL1 Myeloid cell leukemia sequence 1 (BCL2-related) 5.3 21.5 4.1
NM_007289 MME Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) 9.5 29.5 3.1
NM_013416 NCF4 Neutrophil cytosolic factor 4 (40 kDa) 20.0 58.6 2.9
AF171938 NUMB Numb homolog (Drosophila) 3.2 11.6 3.7
NM_023914 P2RY13 purinergic receptor P2Y, G-protein coupled, 13, GPR86 8.7 32.0 3.7
NM_014143 PDCD1LG1 programmed cell death 1 ligand, B7-H1 0.3 5.1 15.3
NM_000442 PECAM1 Platelet/endothelial cell adhesion molecule (CD31 antigen) 6.2 12.5 2.0
NM_001198 PRDM1 PR domain containing 1, with ZNF domain 0.8 6.8 8.9
NM_000962 PTGS1 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.3 8.6 29.5
NM_002838 PTPRC Protein tyrosine phosphatase, receptor type, C 55.9 159.7 2.9
NM_002881 RALB V-ral simian leukemia viral oncogene homolog B (ras related-GTP binding protein) 5.2 15.8 3.0
NM_004761 RGL2 ral guanine nucleotide dissociation stimulator-like 2, RAB2 3.0 8.9 3.0
NM_005621 S100A12 S100 calcium binding protein A12 (calgranulin C) 62.9 164.0 2.6
NM_002964 S100A8 S100 calcium binding protein A8 (calgranulin A) 791.4 2,017.6 2.5
NM_002965 S100A9 S100 calcium binding protein A9 (calgranulin B) 1,152.7 2,697.1 2.3
D83782 SCAP SREBP CLEAVAGE-ACTIVATING PROTEIN 0.3 2.6 7.5
NM_022464 SIL1 Endoplasmic reticulum chaperone SIL1, homolog of yeast 0.3 5.0 14.9
NM_004171 SLC1A2 Solute carrier family 1 (glial high affinity glutamate transporter), member 2 7.5 32.9 4.4
NM_001045 SLC6A4 Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 22.8 44.5 2.0
NM_003105 SORL1 Sortilin-related receptor, L(DLR class) A repeats-containing 31.9 89.7 2.8
NM_003153 STAT6 Signal transducer and activator of transcription 6, interleukin-4 induced 1.6 7.9 5.0
NM_003263 TLR1 Toll-like receptor 1 10.4 28.6 2.8
NM_003841 TNFRSF10C Tumour necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 8.9 39.6 4.5
NM_006573 TNFSF13B Tumour necrosis factor (ligand) superfamily, member 13b 9.2 22.4 2.4
NM_003329 TXN Thioredoxin 9.0 24.8 2.8
  1. Avg. control, average (normalised) intensity in controls; Avg. patients = average (normalised) intensity in patients; Ratio P/C, fold difference between patients and controls.