Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?

Table 2 Characteristics of patients included in the LE skin biopsies: cumulative ACR criteria, autoantibody specificities, and medication

ACR criteria numbered according to Bombardier et al. [19]: 1, malar (or 'butterfly') rash; 2, discoid rash; 3, sensitivity to light, or photosensitivity; 4, oral ulcers; 5, arthritis; 6, serositis; 7, kidney disorder; 8, neurologic disorder; 9, blood abnormalities; 10, positive antiphospholipid antibody test; 11, immunologic disorder, including lupus anticoagulant, positive anti-double-stranded DNA, false-positive syphilis test, or positive anti-Smith test (such as anticardiolipin). + and - indicate cumulative presence or absence, respectively, of a particular criterion. In the leftmost column, +/- indicates biopsies containing SBCs but no apparent co-localisation, +/+ indicates biopsies containing co-localisation of inflammatory lesions and SBCs, and - indicates biopsies without SBCs. ACR, American College of Rheumatology; co-loc, co-localisation; F, female, LE, lupus erythematosus; M, male; SBC, sunburn cell; UVB, ultraviolet B light.

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