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Table 3 Change in gene expression, mean 2-ΔΔCT values, significance and power of comparisons between normal and OA canine articular cartilage

From: Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction

Gene Number of samples in which expression was detected 2-ΔΔCT normal 2-ΔΔCT OA Fold change in expression (diseased versus normal) Mann-Whitney U test p value Power
TIMP4 27 0.109 0.043 -0.608 0.0094 0.859
TIMP2 28 3.959 1.664 -0.580 0.0020 0.844
ADAMTS5 16 0.031 0.019 -0.551 0.8478 0.175
SDHA 28 0.323 0.234 -0.275 0.0476 0.722
VIM 28 32.742 28.909 -0.117 0.5493 0.195
TBP 28 0.106 0.106 0.001 0.8178 0.051
DCN 28 73.034 74.253 0.017 0.5190 0.059
GAPDH 28 1.548 1.648 0.064 0.9633 0.105
RPL13A 28 7.048 7.722 0.096 0.3814 0.275
CTSB 26 0.280 0.476 0.698 0.0060 0.886
AGC 28 0.082 0.155 0.887 0.1670 0.778
TNC 28 2.700 5.205 0.927 0.0099 0.886
BGN 28 15.511 30.984 0.998 0.0043 0.976
CTSD 28 0.148 0.295 0.999 0.0066 0.944
COL9A3 27 0.231 0.546 1.365 0.0304 0.633
TIMP1 28 0.551 1.468 1.663 0.0008 0.853
LUM 28 1.635 4.476 1.738 0.0015 0.991
CSPG2 27 0.079 0.279 2.530 0.0005 0.981
COL5A1 28 0.615 2.188 2.555 0.0069 0.887
COL3A1 26 10.573 37.867 2.581 0.0011 0.982
COL1A2 28 0.805 6.941 7.621 0.0043 0.737
MMP13 26 0.014 0.161 10.322 0.0010 0.857
COL2A1 27 1.412 23.583 15.705 0.0001 0.779
  1. ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif, 5; AGC, aggrecan; BGN, biglycan; COL1A2, type I collagen, alpha two chain; COL2A1, type II collagen alpha 1 chain; COL3A1, type III collagen alpha 1 chain; COL5A1, type V collagen alpha 1 chain; COL9A3, type IX collagen alpha 3 chain; CSPG2, chondroitin sulphate proteoglycan 2; CTSB, cathepsin B; CTSD, cathepsin D; DCN, decorin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LUM, lumican; MMP13, matrix metalloproteinase 13; OA, osteoarthritis; RPL13A, ribosomal protein L13a; SDHA, succinate dehydrogenase complex, subunit A; TBP, TATA box binding protein; TIMP1, tissue inhibitor of metalloproteinase 1; TIMP2, tissue inhibitor of metalloproteinase 2; TIMP4, tissue inhibitor of metalloproteinase 4; TNC, Tenascin C; VIM, vimentin.