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Table 3 Proteins whose quantity in BALF did not significantly vary between SScFib+ and SScFib- patients

From: Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis

Spot no.

Protein

Identification method

1

1β glycoprotein

GM

2

Hemopexin

GM

3

Transferrin

GM

4

Albumin

GM

5

Ig heavy chain α

GM

6

Vitamin D-binding protein

GM

7

α1-antitrypsin

GM, Ab

8

α1-antichymotrypsin

GM, Ab

9

α1-HS-glycoprotein

GM

10

Leucin-rich α2-glycoprotein

GM

11

Fibrinogen γ A chain

GM, Ab

12

Ig heavy chain γ

GM

14

Haptoglobulin 1β chain

GM

15

Pulmonary surfactant-associated protein A

GM

16

Apolipoprotein A1

GM, Ab

17

Ig light chain κ, λ

GM, Ab

18

Serum retinol-binding protein

GM

20

Transthyretin

GM, Ab

21

Immunoglobulin-binding factor

GM

22

Calgranulin A

GM

23

Hemoglobin β chain

GM

24

ERP60 (protein disulfide isomerase)

GM, Ab

25

α1-antitrypsin (fragment)

GM, Ab

26

Ig J chain

GM

27

C-reactive protein

GM

28–30

Apolipoprotein A1 (fragment)

GM, Ab

31

Calcyphosine

GM

32

TCTP (translationally controlled tumor protein)

GM

33

ATP synthase δ chain mitochondrial

GM

34

L-FABP (liver fatty acid-binding protein)

GM

  1. Spot quantity was assessed by PDQUEST 7.1 software on two BALF gel maps of individual SScFib+ (n = 9) and SScFib- (n = 6) patients. Spot quantity between SScFib+ and SScFib- patients did not differ significantly (Mann–Whitney U test, p > 0.05). Spot no. refers to the annotations in Figure 1. BALF, bronchoalveolar lavage fluid; SScFib+, systemic sclerosis patients with functional lung fibrosis and signs of lung fibrosis on high-resolution computed tomography; SScFib-, SSc patients with no signs and symptoms of lung fibrosis; GM, gel matching with plasma two-dimensional gel electrophoresis database from Swiss-PROT [17] and published two-dimensional gel electrophoresis BALF maps [5,6]; Ab, immunoblotting.