TY - JOUR AU - McDougall, Jason J. PY - 2006 DA - 2006/11/10 TI - Arthritis and Pain. Neurogenic origin of joint pain JO - Arthritis Research & Therapy SP - 220 VL - 8 IS - 6 AB - Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the sensory innervation of diarthroidal joints and discusses the neurophysiological processes that lead to the generation of painful sensation. During inflammation, joint nerves become sensitized to mechanical stimuli through the actions of neuropeptides, eicosanoids, proteinase-activated receptors and ion channel ligands. The contribution of immunocytes to arthritis pain is also reviewed. Finally, the existence of an endogenous analgesic system in joints is considered and the reasons for its inability to control pain are postulated. SN - 1478-6354 UR - https://doi.org/10.1186/ar2069 DO - 10.1186/ar2069 ID - McDougall2006 ER -