Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis

Table 3 Correlation between α-actinin-binding antibody levels and clinical findings in patients with SLE

Disease feature	Spearman's rho	p value
Anti-dsDNA Ab ELISA (IU/ml)	0.638	0.0001^a
Anti-dsDNA Ab EliA (IU/ml)	0.601	0.0001^a
Total SLEDAI score	0.378	0.0001^a
ESR	0.254	0.035
CRP (mg/l)	0.236	0.048
C3 (mg/l)	-0.102	0.522
C4 (mg/l)	-0.078	0.623
Age (years)	-0.197	0.051
Creatinin clearance (ml/minute)	0.339	0.199
Proteinuria (g/24 hours)	0.182	0.484
Renal SLICC score	-0.031	0.796
Total SLICC	-0.385	0.0053

^aSignificant results (p < 0.005) after the Bonferroni correction. C3, complement factor 3; C4, complement factor 4; CRP, C-reactive protein; EliA, fluorescence enzyme immunoassay test for anti-double-stranded DNA (Phadia GmbH); ELISA, enzyme-linked immunosorbent assay; ESR, erythrocyte sedimentation rate; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease activity index; SLICC, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus.

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