Table 1 List of genes upregulated in rheumatoid arthritis/osteoarthritis microarray analysis (HI380)
Genes upregulated in RA fibroblast-like synoviocytesa | Functions | RA/OA FLS ratiob |
|---|---|---|
CD1A antigen, α polypeptide | T cell activation | 2.6 |
CD3D antigen, δ polypeptide (TiT3 complex) | T cell activation | 3.7 |
MLN51 gene | Highly expressed in immature DCs | 6.8 |
CD6 antigen | T cell activation | 2.5 |
CD21 antigen | B cell activation | 2.1 |
CD24 antigen (small cell lung carcinoma cluster 4 antigen) | Unknown for human CD24 | 4.3 |
CD26 antigen | T cell activation | 4.1 |
CD32 antigen (Fcγ receptor II) | Formation of immune complexes | 2.2 |
CD33 antigen (gp67) | Inhibition of myeloid cell proliferation | 3.8 |
CD36 antigen (collagen type I receptor, thrombospondin receptor) | Recognition and phagocytosis of apoptotic cells | 2.5 |
CD42b antigen | Adhesion or migration | 4.5 |
CD79A antigen (immunoglobulin-associated α) | B cell activation | 2.4 |
CD171 antigen | T cell activation | 3.6 |
CD206 antigen (macrophage mannose receptor) | Apoptosis or endocytosis | 2.8 |
B cell linker protein (SLP65: BLNK) | B cell activation | 4.0 |
Ig superfamily protein (Z39IG) | Formation of immune complexes | 4.2 |
T cell transcription factor 4 (TCF-4) | Enhancement of the release of extracellular matrix proteins | 2.1 |
IL-1 receptor type I | T cell activation | 2.4 |
IL-7 receptor | T and B cell activation | 2.5 |
IL-8 | Migration | 3.0 |
IL-9 | T and mast cell activation | 2.7 |
IL-17 | T cell activation | 4.6 |
Colony-stimulating factor 2 receptor, β, low-affinity (granulocyte – macrophage); CSF-2RB | Cell cycle regulation | 2.3 |
Colony-stimulating factor 3 receptor (granulocyte) | Cell cycle regulation | 2.9 |
Methyl-CpG-binding domain protein 1 (MBD1) | Cell cycle regulation | 2.2 |