Table 3 Relative signal values of inflammatory genes significantly affected by IL-1 and/or glucosamine
From: Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β
Gene | Treatment group | |||
|---|---|---|---|---|
No glucosamine, no IL-1 | Glucosamine, no IL-1 | IL-1, no glucosamine | Glucosamine with IL-1 | |
Arginosuccinate synthetase | 6.3 | 19.4 | 2247.3 | 267.2 |
β-Nerve growth factor | 16.1 | 21.6 | 196.2 | 13.0 |
Bone morphogenetic protein 2 | 42.7 | 57.7 | 375.4 | 100.2 |
Bone morphogenetic protein 4 | 494.9 | 77.3 | 147.7 | 68.2 |
Bone morphogenetic protein 6 | 60.9 | 13.9 | 435.9 | 85.9 |
Bone morphogenetic protein 7 | 0.9 | 5.8 | 76.2 | 8.2 |
CCL3 (MIP-1a) | - | 0.1 | 690.7 | 2.6 |
CCL5 (RANTES) | 2.1 | 2.7 | 310.1 | 8.1 |
CCL7 (MCP-3) | 32.2 | 69.4 | 3076.0 | 662.8 |
CCL22 (MDC) | 0.3 | 0.6 | 47.2 | 5.4 |
Cdc42 GTPase inhibiting protein | 105.0 | 116.5 | 189.4 | 124.4 |
Colony-stimulating factor 1 | 126.9 | 51.1 | 307.8 | 140.8 |
Colony-stimulating factor 2 | - | 20.1 | 1210.7 | 17.6 |
Colony-stimulating factor 3 | - | 6.0 | 1253.7 | 6.5 |
CXCL1 (GROa) | 168.2 | 36.6 | 1730.6 | 496.2 |
CXCL2 (GROb) | - | 37.5 | 2988.2 | 92.4 |
CXCL5 (LIX) | 2.0 | 2.4 | 441.3 | 16.2 |
CXCL10 (IP-10) | 10.7 | 8.1 | 74.4 | 15.6 |
CXCL11 (I-TAC) | - | - | 110.2 | 3.4 |
CXCL12 (SDF-a/b) | 122.8 | 5.9 | 88.7 | 10.9 |
Cyclooxygenase 1 | 184.0 | 593.4 | 192.2 | 493.1 |
Cyclooxygenase 2 | 61.9 | 117.0 | 3493.9 | 405.5 |
Cysteine knot superfamily 1 (bone morphogenetic protein antagonist 1) | 460.4 | 308.6 | 2174.9 | 732.7 |
Cytokine-induced neutrophil chemoattractant-2 | 15.2 | 54.4 | 3466.1 | 624.2 |
Dual-specificity phosphatase 6 | 179.9 | 88.9 | 658.7 | 109.9 |
Endothelial PAS domain protein 1 | 69.9 | 38.0 | 208.9 | 52.2 |
Fibroblast growth factor 7 | 1294.4 | 1078.9 | 1318.9 | 1745.9 |
Fibroblast growth factor 9 | 12.0 | 29.5 | 155.7 | 26.7 |
Fibroblast growth factor receptor 1 | 605.2 | 653.7 | 329.3 | 638.5 |
I-κBα | 126.9 | 81.7 | 1108.4 | 399.0 |
I-κBβ | 55.6 | 96.6 | 298.2 | 139.2 |
I-κBγ (NF-κB p105 subunit) | 124.2 | 107.9 | 471.2 | 163.6 |
Insulin-like growth factor binding protein 3 | 81.6 | 7.4 | 249.9 | 10.4 |
Insulin-like growth factor binding protein 5 | 174.4 | 569.0 | 737.8 | 229.5 |
IL-1α | 1.5 | 3.2 | 175.3 | 4.5 |
IL-1β | - | 2.4 | 119.4 | 2.7 |
IL-6 | 57.3 | 53.4 | 1717.8 | 159.0 |
IL-11 | - | - | 124.4 | - |
IL-13 receptor, α 1 | 174.8 | 144.5 | 337.4 | 148.0 |
IL-23α subunit p19 | - | - | 766.5 | - |
Janus kinase 2 | 89.7 | 102.9 | 251.0 | 128.7 |
JunB proto oncogene | 129.5 | 89.0 | 377.8 | 148.4 |
Mitogen-activated protein kinase phosphatase (CPG21) | 19.1 | 47.5 | 300.2 | 52.3 |
Nitric oxide synthase 2 | 0.1 | 2.1 | 1033.9 | 66.1 |
Ornithine aminotransferase | 1080.5 | 1125.0 | 868.6 | 1059.1 |
Ornithine decarboxylase antizyme inhibitor | 322.1 | 239.4 | 336.9 | 186.6 |
Phospholipase A2, group 2A | 175.5 | 44.7 | 2085.9 | 358.0 |
Phospholipase A2, group 4A | 269.9 | 303.2 | 668.2 | 339.7 |
Phospholipase A2, group 5 | 44.0 | 18.2 | 260.7 | 66.7 |
Platelet-derived growth factor A | 439.8 | 492.9 | 745.9 | 597.5 |
Prostaglandin E2 synthase | 32.8 | 46.9 | 3845.8 | 183.7 |
Pyrroline-5-carboxylate | 602.5 | 643.8 | 348.3 | 609.3 |
Rel-B | 31.6 | 28.7 | 186.2 | 71.5 |
Small inducible cytokine A2 | 221.4 | 711.0 | 4835.8 | 2945.5 |
Small inducible cytokine A20 | 26.9 | 137.8 | 4206.1 | 1609.7 |
Solute carrier family 7 (cationic amino acid transporter), member 8 | 8.1 | 19.4 | 560.3 | 21.7 |
Sox-4 | 533.0 | 460.8 | 248.5 | 572.2 |
TNF-induced protein 6 | 119.8 | 49.3 | 262.3 | 71.1 |