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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis

Figure 1

Antibody-mediated arthritis in mice. (a) Collagen antibody-induced arthritis disease curve in BALB/c mice. A cocktail of arthritogenic mAb (M2139 + CIIC1), isotype control (L243 + G11) or phosphate-buffered saline (PBS) was intravenously injected on day 0 (n = 10 to 12). All the mice received lipopolysaccharide (50 μg/mouse intraperitoneally) on day 5. Arthritis was monitored for 30 days. None of the control mice developed arthritis. Clinical arthritis on day 10 was shown (b) after antibody transfer in B10.RIII mice (left, normal paw; right, arthritis paw), and (c) after antibody transfer and lipopolysaccharide injection in BALB/c mice (left, arthritis paw; right, normal paw). N, number of mice in each group. Error bars denote standard error of the mean.

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