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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis

Figure 2

Possible interactions of effector molecules in the collagen antibody-induced arthritis joint. AA, arachidonic acid; C1q, C2a, C3, C3a, C4b, C5a and B (factor B), complement components; CCL3, chemokine (C-C motif) ligand 3; COX2, cyclooxygenase-2; EP4, prostaglandin receptor; FcγR, Fcγ receptor; IC, immune complex; IL, interleukin; LTB4, leukotriene B4; Mφ, macrophages; M, mast cells; MIF, macrophage migration inhibitory factor; N, neutrophils; PGE2, prostaglandin E2; TGF, transforming growth factor; TNF, tumour necrosis factor.

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