Skip to main content

Table 1 Evaluation of phenotypic markers of normal and osteoarthritis (OA) subchondral osteoblasts

From: The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein

Source Alkaline phosphatase (nmol/mg protein/30 min) Osteocalcin (ng/mg protein/48 hours) Collagen type I (ng/mg protein/48 hours)
Normal (n = 11) 624.7 ± 88.8 176.6 ± 24.7 285.3 ± 17.1
OA (n = 26) 1333.1 ± 215.7 264.0 ± 20.7 370.4 ± 8.1
  p < 0.005 p < 0.05 p < 0.015
  1. Confluent osteoblasts were incubated for their last 2 days of culture in Ham's F12/DMEM medium containing 2% charcoal-treated fetal bovine serum and 50 nM 1,25-dihydroxyvitamin D3. Values are means ± SEM. The statistical analysis compared OA values with their respective normal values.
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us