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Table 1 Evaluation of phenotypic markers of normal and osteoarthritis (OA) subchondral osteoblasts

From: The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein

Source

Alkaline phosphatase (nmol/mg protein/30 min)

Osteocalcin (ng/mg protein/48 hours)

Collagen type I (ng/mg protein/48 hours)

Normal (n = 11)

624.7 ± 88.8

176.6 ± 24.7

285.3 ± 17.1

OA (n = 26)

1333.1 ± 215.7

264.0 ± 20.7

370.4 ± 8.1

 

p < 0.005

p < 0.05

p < 0.015

  1. Confluent osteoblasts were incubated for their last 2 days of culture in Ham's F12/DMEM medium containing 2% charcoal-treated fetal bovine serum and 50 nM 1,25-dihydroxyvitamin D3. Values are means ± SEM. The statistical analysis compared OA values with their respective normal values.
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Arthritis Research & Therapy

ISSN: 1478-6362

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