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Figure 3 | Arthritis Research & Therapy

Figure 3

From: The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

Figure 3

Effect of macrophage depletion on cytokine and matrix metalloproteinase (MMP) production in osteoarthritis (OA) synovial cells. OA cultures of synovial cells were either left intact or macrophage-depleted, as described in Materials and methods. Cells were left to adhere for 24 hours before the supernatants were removed for enzyme-linked immunosorbent assay analysis of cytokines and MMPs. Data are expressed as the percentage of cytokine/MMP production in the depleted culture as compared with the undepleted one. The standard error of the mean is given (n = 7–9). IL, interleukin; MCP, monocyte chemoattractant protein; TNF, tumour necrosis factor.

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Arthritis Research & Therapy

ISSN: 1478-6362

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