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Table 1 Variables in three recent studies of apoptotic cells induced by photoprovocation

From: Shining light on lupus and UV

  Reefman et al. [1] Kuhn et al. [11] Jannsens et al. [12]
Patients SLE DLE, SCLE, TLE DLE, SCLE, SLE
Photosensitive 6/15 All All
Treatment Steroids, azathioprine No steroids 3/22 steroids
Controls Healthy SLE, healthy Healthy
UV UVB, 2MEDs UVA or UVB, 1.5 MED UVB, 6 MEDs
Site Buttock Upper back Buttock
Frequency Once Three times Once
Apoptosis detection Sunburn cells, casp3 ISNT, TUNEL, casp3 Casp3
Time analyzed (days) 3, 10 1, 3 and up to 28 1, 2, 3
  1. Casp3, activated caspase 3; DLE, discoid lupus erythematosus; ISNT, in situ nick translation; MED, minimal erythemal dose; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematosus; TLE, tumid lupus erythematosus; TUNEL, in situ nick end labeling.