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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients

Figure 3

Relative polymerase chain reaction product/GAPDH ratios for alkaline phosphatase (ALP), osteocalcin (OCN), and osteopontin (OPN) and the relative ratio of COL1A1/COL1A2. mRNA expression in intertrochanteric trabecular bone was compared between the osteoarthritis (OA) (n = 15) and control (n = 13) groups. Patients with OA had significantly elevated (a) ALP/GAPDH (p < 0.002), (b) OCN/GAPDH (p < 0.0001), (c) OPN/GAPDH (p < 0.05), and (d) COL1A1/COL1A2 (p < 0.0001) mRNA ratios versus controls. Data are expressed as parametric mean ± standard deviation (open diamond) and non-parametric median (closed diamond) and quartile (dash) range. COL1A, collagen type I alpha chain; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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Arthritis Research & Therapy

ISSN: 1478-6362

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