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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients

Figure 7

Associations between osteocalcin (OCN)/GAPDH mRNA and the histomorphometric parameters of bone tissue volume (BV/TV), trabecular number (Tb.N), and trabecular separation (Tb.Sp). The relative OCN/GAPDH mRNA expression and architectural parameters were determined in intertrochanteric trabecular bone from osteoarthritis (OA) (n = 14) and control (n = 13) individuals. (a) In controls, there was a significant increase in BV/TV with increasing OCN/GAPDH mRNA (BV/TV = 27.7 [OCN/GAPDH] – 6.3; r = 0.82, p < 0.0007) in contrast to the patients with OA (BV/TV = -7.57 [OCN/GAPDH] + 17.38; r = -0.31, p = not significant [NS]). (b) A significant increase in Tb.N with increasing OCN/GAPDH mRNA was observed in controls (Tb.N = 1.16 [OCN/GAPDH] + 0.05; r = 0.56, p < 0.05). In OA, there was no significant association between Tb.N and OCN/GAPDH mRNA (Tb.N = 0.09 [OCN/GAPDH] + 1.03; r = 0.04, p = NS). (c) In controls, there was a significant decline in Tb.Sp with increasing OCN/GAPDH mRNA (Tb.Sp = -3,977.9 [OCN/GAPDH] + 3,626.1; r = -0.64, p < 0.02) and no significant change in Tb.Sp with OCN/GAPDH mRNA in OA individuals (Tb.Sp = -353.5 [OCN/GAPDH] + 1,214.4; r = -0.19, p = NS). GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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