Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients

Table 3 Trabecular bone structure and bone turnover indices in osteoarthritis and control intertrochanteric bone samples

Histomorphometric parameter	Osteoarthritis	Control
	(n = 14)	(n = 13)
BV/TV (percentage)	10.4 ± 4.1	7.6 ± 3.1
BS/TV (mm²/mm³)	2.3 ± 0.7	1.3 ± 0.4^a
BS/BV (mm²/mm³)	20.5 (17.3–28.6)	18.0 (14.7–20.6)
Tb.Th (μm)	98 ± 39	111 ± 34
Tb.Sp (μm)	817 (760–892)	1,406 (1,203–2,202)^b
Tb.N (number/mm)	1.11 ± 0.36	0.63 ± 0.19^a
OV/TV (percentage)	0.12 (0.07–0.15)	0.05 (0.04–0.13)
OS/BS (percentage)	7.8 (3.7–9.7)	7.2 (4.2–9.7)
ES/BS (percentage)	4.6 (3.4–6.4)	4.5 (2.0–7.6)

^ap < 0.0003; ^bp < 0.0001. Parametric values are mean ± standard deviation. Non-parametric values are median (quartiles). BS/BV, specific surface of bone; BS/TV, bone surface density; BV/TV, bone tissue volume; ES/BS, eroded surface; OS/BS, osteoid surface; OV/TV, osteoid volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness.

ISSN: 1478-6362