Mechanism | Model | Reference (year) |
---|---|---|
Soluble factors: TGF-β, HGF. Reversible | Human in vitro. MLRs, DCs and mitogen-stimulated T cells (CD4 and CD8) | [34] (2002) |
IDO | Human in vitro. MLRs | [37] (2004) |
Classical anergy (IL-2 reversible) | Murine in vitro. Antigen (MOG) and mitogen (ConA) stimulated T cells | [58] (2005) |
Increased PGE2 | Human in vitro. Mitogen (PHA) stimulation | [28] (2005) |
G1 cell cycle arrest (irreversible) | Murine in vitro. Cognate antigenic peptide primed stimulator lymphocytes | [2] (2005) |
Apoptosis of activated but not resting T cells. IDO mediated | Human in vitro. MLRs | [75] (2005) |
Nitric oxide reduction of STAT5 phosphorylation in lymphocytes | Murine in vitro | [76] (2006) |