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Table 2 Mean concentrations of prostaglandin E2, IL-6, and matrix metalloproteinase 3 in culture media of fibroblast-like synovial cells determined by ELISAs

From: Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells

 

Group 1

Group 2

Group 3

Group 4

Prostaglandin E2 (pg/ml)

15.43 ± 15.43

21,025a ± 6,828

2,998b ± 887

2925b ± 1,669

IL-6 (pg/ml)

1.77 ± 1.74

41.33c ± 16.18

9.49 ± 3.53

6.79 ± 3.11

Matrix metalloproteinase 3 (pg/ml)

2.60 ± 1.36

6.31d ± 0.26

2.96 ± 1.08

1.80 ± 0.90

  1. Data presented as the mean ± standard error of the mean. Triplicate samples were performed for each of the three individual donors in the four groups. Group 1, unchallenged control; group 2, lipopolysaccharide control; group 3, pretreatment and sustained treatment with lower molecular weight hyaluronan product; group 4, pretreatment and sustained treatment with higher molecular weight hyaluronan product. a,bSignificant difference exists (P < 0.05). c,dSignificant difference exists (P < 0.01).
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Arthritis Research & Therapy

ISSN: 1478-6362

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