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Table 2 Mean concentrations of prostaglandin E2, IL-6, and matrix metalloproteinase 3 in culture media of fibroblast-like synovial cells determined by ELISAs

From: Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells

  Group 1 Group 2 Group 3 Group 4
Prostaglandin E2 (pg/ml) 15.43 ± 15.43 21,025a ± 6,828 2,998b ± 887 2925b ± 1,669
IL-6 (pg/ml) 1.77 ± 1.74 41.33c ± 16.18 9.49 ± 3.53 6.79 ± 3.11
Matrix metalloproteinase 3 (pg/ml) 2.60 ± 1.36 6.31d ± 0.26 2.96 ± 1.08 1.80 ± 0.90
  1. Data presented as the mean ± standard error of the mean. Triplicate samples were performed for each of the three individual donors in the four groups. Group 1, unchallenged control; group 2, lipopolysaccharide control; group 3, pretreatment and sustained treatment with lower molecular weight hyaluronan product; group 4, pretreatment and sustained treatment with higher molecular weight hyaluronan product. a,bSignificant difference exists (P < 0.05). c,dSignificant difference exists (P < 0.01).