Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis

Table 2 Summary of the small-effect QTL identified in this study

Loci	Chromosome	Peak marker	Position (Mb)	P value	Susceptibility allele	Overlapping QTL in mouse models of RA	Snyternic region linked to RA (linked marker)
1^a,b,c	5	D5Mit348	23,9	0.00691	DBA/1	Cia13
2^b	5	D5Mit425	119,1	0.04397	DBA/1	Cia14	22q11 (D22S264), 12p13-q24 (D12S95)
3^a,b,c	6	D6Mit14	145,7	0.00315	FVB/N		12p13-pter (D12S99)
4^a,b,c	7	D7Mit248	59,3	0.03250	DBA/1
5^a,c	10	D10Mit261	85,1	0.00647	DBA/1	Cia8	21q22-qter (D21S268), 10q22-23 (D10S2327)
6^b,c	11	D11Mit214	115,2	0.00521	DBA/1	Pgia7	17q21-q25 (D17S1301)
7^c	16	D16Mit138	45,4	0.01499	FVB/N		3q29-qter (D3S1311)
8^c	17	D17Mit197	18,3	0.02994	FVB/N

^aIdentified in all F2 290 progeny. ^bIdentified in 76 C5+/+ F2 progeny. ^cIdentified in 133 C5+/- F2 progeny. QTL, quantitative trait loci; RA, rheumatoid arthritis.

ISSN: 1478-6362