Skip to main content

Table 3 Summary of the small-effect QTL candidate genes

From: Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis

Gene Chr. Position (Mb) Description Difference between DBA/1 and FVB/N strains Difference during CIA in DBA/1 strain
     Phase Fold changea Phase Fold changeb
Steap4 5 7.9 STEAP family member 4 NC/PI/CA 12.9/7.1/-5.9 CA -8.3
Add1 5 33.6 Adducin 1 (alpha) NC/PI 5.1/3.3 CA -4.6
Wdr1 5 37.8 WD repeat domain 1 NC/PI/OA/CA 4.9/3.5/2.4/-3.2 CA -7.1
Cd38 5 43.1 CD38 antigen NC/PI 5.7/4.0 CA -3.6
Tgfbr3 5 106.2 Transforming growth factor, beta receptor III NC/PI/CA 8.7/6.9/-3.2 CA -3.9
Oas1a 5 120.1 2'-5' Oligoadenylate synthetase 1A NC -2.5 OA 2.7
Baz1b 5 134.1 Bromodomain adjacent to zinc finger domain, 1B NC/PI 5.9/5.7 CA -6.7
Lfng 5 139.5 Lunatic fringe gene NC/PI/OA 8.8/4.6/2.5 CA -7.7
Gna12 5 139.7 Guanine nucleotide binding protein, alpha 12 NC/PI/OA 4.1/3.7/3.3 CA -3.5
8430419L09Rik 6 135.2 RIKEN cDNA 8430419L09 gene NC/PI/OA 17.8/12.8/3.3 CA -4.2
Etnk1 6 143.2 Ethanolamine kinase 1 NC/PI/OA 4.6/3.9/2.6 CA -5.6
Nnp1 10 78.05 Novel nuclear protein 1 NC 3.0 CA -3.5
Kpnb1 11 97.2 Karyopherin (importin) beta 1 NC/PI/OA/CA 12.1/7.3/3.2/-20 CA -50
Stat5a 11 100.9 Signal transducer and activator of transcription 5A NC/PI 5.3/3.0 CA -4.6
Pscd1 11 118.2 Pleckstrin homology, Sec7 and coiled-coil domains 1 NC/PI/OA/CA 4.7/3.6/2.4/-4 CA -11
Mapk8ip3 17 23.07 Mitogen-activated protein kinase 8 interacting protein 3 NC/PI 3.9/2.5 CA -3.1
Mapk14 17 26.8 Mitogen activated protein kinase 14 NC/PI/OA/CA 9.1/4.7/3.1/-14 CA -33.3
A430107D22Rik 17 30.5 RIKEN cDNA A430107D22 gene NC 3.7 CA -5
Hspa1a 17 33 Heat shock protein 1A PI/CA -3.8/-4.6 PI/OA 3.8/5.4
H2-Q10 17 33.5 Histocompatibility 2, Q region locus 10 NC/PI/OA/CA 3.3/4.2/2.5/5.3 CA -3
Gabbr1 17 35.1 Gamma-aminobutyric acid receptor 1 NC/PI 4.9/2.5 CA -6.3
  1. aFold change calculated by comparing DBA/1 with FVB/N. bFold change calculated by comparing post-immunisation (PI), onset of arthritis (OA) and chronic arthritis (CA) with naive control (NC), respectively. Chr., chromosome; CIA, collagen-induced arthritis.