Table 3 Summary of the small-effect QTL candidate genes
Gene | Chr. | Position (Mb) | Description | Difference between DBA/1 and FVB/N strains | Difference during CIA in DBA/1 strain | ||
|---|---|---|---|---|---|---|---|
Phase | Fold changea | Phase | Fold changeb | ||||
Steap4 | 5 | 7.9 | STEAP family member 4 | NC/PI/CA | 12.9/7.1/-5.9 | CA | -8.3 |
Add1 | 5 | 33.6 | Adducin 1 (alpha) | NC/PI | 5.1/3.3 | CA | -4.6 |
Wdr1 | 5 | 37.8 | WD repeat domain 1 | NC/PI/OA/CA | 4.9/3.5/2.4/-3.2 | CA | -7.1 |
Cd38 | 5 | 43.1 | CD38 antigen | NC/PI | 5.7/4.0 | CA | -3.6 |
Tgfbr3 | 5 | 106.2 | Transforming growth factor, beta receptor III | NC/PI/CA | 8.7/6.9/-3.2 | CA | -3.9 |
Oas1a | 5 | 120.1 | 2'-5' Oligoadenylate synthetase 1A | NC | -2.5 | OA | 2.7 |
Baz1b | 5 | 134.1 | Bromodomain adjacent to zinc finger domain, 1B | NC/PI | 5.9/5.7 | CA | -6.7 |
Lfng | 5 | 139.5 | Lunatic fringe gene | NC/PI/OA | 8.8/4.6/2.5 | CA | -7.7 |
Gna12 | 5 | 139.7 | Guanine nucleotide binding protein, alpha 12 | NC/PI/OA | 4.1/3.7/3.3 | CA | -3.5 |
8430419L09Rik | 6 | 135.2 | RIKEN cDNA 8430419L09 gene | NC/PI/OA | 17.8/12.8/3.3 | CA | -4.2 |
Etnk1 | 6 | 143.2 | Ethanolamine kinase 1 | NC/PI/OA | 4.6/3.9/2.6 | CA | -5.6 |
Nnp1 | 10 | 78.05 | Novel nuclear protein 1 | NC | 3.0 | CA | -3.5 |
Kpnb1 | 11 | 97.2 | Karyopherin (importin) beta 1 | NC/PI/OA/CA | 12.1/7.3/3.2/-20 | CA | -50 |
Stat5a | 11 | 100.9 | Signal transducer and activator of transcription 5A | NC/PI | 5.3/3.0 | CA | -4.6 |
Pscd1 | 11 | 118.2 | Pleckstrin homology, Sec7 and coiled-coil domains 1 | NC/PI/OA/CA | 4.7/3.6/2.4/-4 | CA | -11 |
Mapk8ip3 | 17 | 23.07 | Mitogen-activated protein kinase 8 interacting protein 3 | NC/PI | 3.9/2.5 | CA | -3.1 |
Mapk14 | 17 | 26.8 | Mitogen activated protein kinase 14 | NC/PI/OA/CA | 9.1/4.7/3.1/-14 | CA | -33.3 |
A430107D22Rik | 17 | 30.5 | RIKEN cDNA A430107D22 gene | NC | 3.7 | CA | -5 |
Hspa1a | 17 | 33 | Heat shock protein 1A | PI/CA | -3.8/-4.6 | PI/OA | 3.8/5.4 |
H2-Q10 | 17 | 33.5 | Histocompatibility 2, Q region locus 10 | NC/PI/OA/CA | 3.3/4.2/2.5/5.3 | CA | -3 |
Gabbr1 | 17 | 35.1 | Gamma-aminobutyric acid receptor 1 | NC/PI | 4.9/2.5 | CA | -6.3 |