The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway

Table 1 Peptides used in this study

Designation	Amino acid sequence	Encoded by HLA-DRB1 alleles
65–79*0401	KDLLEQKRAAVDTYC	0401, 0413, 0416, 0421, 1419, 1421
65–79*0402	KDILEDERAAVDTYC	0402, 0414, 0103, 1102, 1116, 1120, 1121, 1301, 1302, 1304, 1308, 1315, 1315, 1317, 1319, 1322, *1416
65–79*0403	KDLLEQRRAEVDTYC	0403, 0406, 0407, 0417, *0420
65–79*0404	KDLLEQRRAAVDTYC	0404, 0405, 0408, 0410, 0419, 0101, 0102, 1402, 1406, 1409, 1413, 1417, *1420
65–79*1001	KDLLERRRAAVDTYC	*1001
Pentapeptide
1	QKRAA	0401, 0413, 0416, 0421, 1419, 1421
2	QRRAA	0404, 0405, 0408, 0410, 0419, 0101, 0102, 1402, 1406, 1409, 1413, 1417, *1420
3	DERAA	0402, 0414, 0103, 1102, 1116, 1120, 1121, 1301, 1302, 1304, 1308, 1315, 1315, 1317, 1319, 1322, *1416
4	RRRAA	*1001
5	RRRAE	09, 1401, 1404, 1405, 1407, 1408, 1410, 1411, 1414, 1418
6	DRRAA	1601, 1602, 1605, 0415, 11011, 11012, 11041, 11042, 1105, 1106, 11081, 110821109, 1110, 1112, 1115, 1118, 1119, 1122, 1201, 12021, 12022, 12031, 12032, 1305, 1306, 1307, 1311, 1312, 1314, 1321, 0805
7	QARAA	15, 1309
8	QKRGR	03, 0422, *1107
9	QKRLA	Not applicable (modified peptide)
10	QKRAE	Not applicable (modified peptide)
11	QKCLA	Not applicable (modified peptide)
12	QECLA	Not applicable (modified peptide)
13	DKCLA	Not applicable (modified peptide)

A, alanine; C, cysteine; D, aspartic acid; E, glutamic acid; G, glycine; HLA-DRB1, human leukocyte antigen-DRB1; I, isoleucine; K, lysine; L, leucine; Q, glutamine; R, arginine; T, threonine; V, valine; Y, tyrosine.

ISSN: 1478-6362