Influence of soluble mediators on the expression of neurokinin 1 (NK1), bradykinin 2 (B2), and transient receptor potential V1 (TRPV1) receptors in dorsal root ganglion (DRG) neurones. Proportion of DRG neurones with (a) NK1 receptor-like immunoreactivity (IR), (b) B2 receptor-like labelling, and (c) TRPV1 receptor-like immunoreactivity after culturing either in normal medium, or after administration of the supernatant of fibroblast-like synovial (FLS) cells from normal, acutely or chronically inflamed knee joints. #Significant difference to DRG mono-cultures. $Significant difference to co-culture with FLS cells from normal knee joints. AIA, antigen-induced arthritis.