Figure 7

Influence of cyclooxygenase (COX) inhibition on the expression of the neurokinin 1 (NK1) receptors in dorsal root ganglion (DRG) neurones in different co-cultures with fibroblast-like synovial (FLS) cells. Proportions of DRG neurones with NK1 receptor-like immunoreactivity (IR) after culturing in normal medium, in medium with the COX inhibitor indomethacin (1 μmol/l), in medium containing an anti-IL6 antibody (1 μmol/l) or in medium containing normal rat IgG (1 μmol/l). White bars show co-cultures of DRG neurones with FLS cells from normal knee joints, black bars show co-cultures of DRG neurones with FLS cells from acutely inflamed knee joints (day 3), and grey bars show co-cultures of DRG neurones with FLS cells from chronically inflamed joints. ^#Significant difference between untreated and indomethacin-treated co-cultures of DRG neurones and FLS cells from acutely inflamed knee joints.