Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study

Table 1 Concentration of IL-6 and PGE₂ in supernatants from cultured FLS cells and co-cultures from FLS cells and DRG neurones

	PGE₂ (ng/ml)	IL-6 (ng/ml)
DRG neurones	ND	ND
FLS cells, normal knee joints	4.8 ± 2.1	10.6 ± 2.2
FLS cells, acutely inflamed knee joints	28.6 ± 5.2	22.0 ± 4.2
FLS cells, chronically inflamed knee joints	92.9 ± 23.4	NM
DRG neurones + FLS cells, normal knee joints	11.7 ± 3.1	12.8 ± 2.0
DRG neurones + FLS cells, acutely inflamed joints	39.0 ± 4.1	26.0 ± 3.9
DRG neurones + FLS cells, chronically inflamed joints	75.7 ± 18.5	NM

DRG, dorsal root ganglion; FLS, fibroblast-like synovial; IL, interleukin; ND, not detected; NM, not measured; PGE₂, prostaglandin E₂.

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