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Table 2 Histopathologic evaluation of H&E stained cartilage by the Mankin grading method

From: Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial

Items Normal (n = 7) NMS (n = 7) NS (n = 11) P*
Medial tibial plateau
   Structure 0.57 (0.30)a 2.14 (0.46)a 5.27 (0.60)b 0.000
   Cell in tangential zone 0.29 (0.18)a 0.71 (0.18)a 1.50 (0.15)b 0.000
   Cell in transitional and radial zone 1.00 (0.69)a 2.57 (0.43)a 6.05 (0.75)b 0.000
   Pannus formation 0.00 (0.00)a 0.29 (0.18)a 1.18 (0.30)b 0.005
   Sum of scores 1.86 (1.12)a 5.71 (0.84)b 14.00 (0.75)c 0.000
Medial femoral condyle
   Structure 0.57 (0.30)a 1.29 (0.47)ab 2.50 (0.54)b 0.031
   Cell in tangential zone 0.29 (0.18)a 0.43 (0.20)ab 0.95 (0.11)b 0.010
   Cell in transitional and radial zone 1.00 (0.69)a 2.29 (0.68)a 5.36 (0.78)b 0.001
   Pannus formation 0.00 (0.00) 0.43 (0.20) 0.73 (0.24) 0.062
   Sum of scores 1.86 (1.12)a 4.43 (1.17)a 9.55 (1.30)b 0.001
  1. Data represent the means (standard error) for each group. As the severity of cartilage lesions increases, so does the score obtained using the Mankin grading method. The Normal group includes normal articular cartilage group that did not undergo any surgery or treatment. The nutritive mixture solution (NMS) group received NMS after surgery. The normal saline (NS) group received NS after surgery. *Differences among the three groups were considered to be statistically significant when the P value was under 0.05 by one-way analysis of variance and Tukey HSD test, or Kruskal-Wallis test, depending on normality of data. a,b,cData with different letters in the three groups are statistically significantly different.